紫菀根及根茎挥发油中祛痰成分的研究

[Studies on expectorant compounds in volatile oil from root and rhizome of Aster tataricus].

作者信息

Yang Bin, Xiao Yong-Qing, Liang Ri-Xin, Wang Ruo-Jing, Li Wen, Zhang Cun, Cao Ying, Wang Qian-Peng, Wang Lan, Wang Yong-Yan

机构信息

Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.

出版信息

Zhongguo Zhong Yao Za Zhi. 2008 Feb;33(3):281-3.

PMID:18536466

Abstract

OBJECTIVE

To research the expectorant components in volatile oil from the root and rhizome of Aster tataricus.

METHOD

GC-MS was applied to isolate and identify the compounds. In addition, TLC was used to isolate compound, and its structure was elucidated on the basis of spectral data analysis. At the same time, its expectorant effect was observed by method of the excretion quantity of phenol red in trachea of mice.

RESULT

Seven compounds were isolated and identified by GC-MS, they were (R)(-)-p-menth-1-en-4-ol (1), 2-undecanone (2), n-decanoic acid (3), (-)-spathulenol (4), hexahydrofamrnesyl acetone (5), hexadecanoic acid (6), and cis-9, cis-12-octaecadienoic acid (7). A known compound 1-acetoxy-2-ene(E)-4,6- decandiyne was isolated from the root and rhizome of A. tataricus, and it was shown to have expectorant effect.

CONCLUSION

1-Acetoxy-2-ene(E) -4,6- decandiyne, a main compound in volatile oil, had been found to have expectorant effect.

摘要

目的

研究紫菀根及根茎挥发油中的祛痰成分。

方法

采用气相色谱-质谱联用（GC-MS）法分离鉴定化合物。此外，用薄层色谱法（TLC）分离化合物，并根据光谱数据分析阐明其结构。同时，通过小鼠气管酚红排泄量法观察其祛痰作用。

结果

通过GC-MS分离鉴定出7种化合物，分别为（R）（-）-对-薄荷-1-烯-4-醇（1）、2-十一酮（2）、正癸酸（3）、（-）-斯巴醇（4）、六氢法尼基丙酮（5）、十六烷酸（6）和顺-9，顺-12-十八碳二烯酸（7）。从紫菀根及根茎中分离出一种已知化合物1-乙酰氧基-2-烯（E）-4,6-癸二炔，并显示其具有祛痰作用。