Hardie Kim Rachael, Heurlier Karin
Kim Rachael Hardie is at the Institute of Infection, Immunity and Inflammation, Centre for Biomolecular Sciences, University of Nottingham, University Park, Nottingham NG7 2RD, UK.
Nat Rev Microbiol. 2008 Aug;6(8):635-43. doi: 10.1038/nrmicro1916. Epub 2008 Jun 9.
Multicellular bacterial communities (biofilms) abound in nature, and their successful formation and survival is likely to require cell-cell communication--including quorum sensing--to co-ordinate appropriate gene expression. The only mode of quorum sensing that is shared by both Gram-positive and Gram-negative bacteria involves the production of the signalling molecule autoinducer 2 by LuxS. A survey of the current literature reveals that luxS contributes to biofilm development in some bacteria. However, inconsistencies prevent biofilm development being attributed to the production of AI2 in all cases.
多细胞细菌群落（生物膜）在自然界中广泛存在，其成功形成和存活可能需要细胞间通讯——包括群体感应——来协调适当的基因表达。革兰氏阳性菌和革兰氏阴性菌共有的唯一群体感应模式涉及由LuxS产生信号分子自诱导物2。对当前文献的调查表明，luxS在某些细菌中有助于生物膜的形成。然而，存在的不一致性使得不能在所有情况下都将生物膜的形成归因于AI2的产生。
