Kumar Rakesh K, Herbert Cristan, Foster Paul S
Department of Pathology, School of Medical Sciences, University of New South Wales, Sydney, Australia.
Curr Drug Targets. 2008 Jun;9(6):485-94. doi: 10.2174/138945008784533561.
Ovalbumin challenge models of asthma offer many opportunities for increasing our understanding of the pathogenetic mechanisms underlying this disease, as well as for identifying novel therapeutic targets. There is no single "classical" model, because numerous alternatives exist with respect to the choice of mouse strain, method of sensitisation, route and duration of challenge, and approach to assessing the host response. Moreover, the limitations of these models need to be recognised when attempting to interpret experimental findings. Nevertheless, careful use of well-defined models allows investigators to answer specific questions that are otherwise difficult to address.
哮喘的卵清蛋白激发模型为增进我们对该疾病发病机制的理解以及识别新的治疗靶点提供了诸多机会。不存在单一的“经典”模型，因为在小鼠品系的选择、致敏方法、激发途径和持续时间以及评估宿主反应的方法等方面存在众多替代方案。此外，在试图解释实验结果时，需要认识到这些模型的局限性。然而，谨慎使用定义明确的模型可使研究人员回答那些否则难以解决的特定问题。
