Skurtveit Svetlana, Selmer Randi, Tverdal Aage, Furu Kari
Norwegian Institute of Public Health, Division of Epidemiology, P.O. Box 4404 Nydalen, N-0403 Oslo, Norway.
J Clin Epidemiol. 2008 Jul;61(7):714-7. doi: 10.1016/j.jclinepi.2007.11.013.
Validation studies of self-reported medication use in adolescents have been scarce. The objective of this study was to estimate the sensitivity and specificity of self-reported use of medication using a prescription database as reference standard.
The study population consisted of a cohort of 2,613 adolescents aged 15-16 years from the Norwegian youth health survey in 2004 and 2005. Self-reported data on medication use were compared with data from the Norwegian Prescription Database which contains information from all prescription dispensed at Norwegian pharmacies.
Sensitivity for self-reported questions on medication use was highest for contraceptive pills 99.2% (95% CI 97.7-100) compared to antiasthmatics 79.1% (66.9-91.2), painkillers 48.5% (36.7-60.4), and psychotropic drugs 75.0% (35.6-95.6). Specificity values of self-reported information of psychotropic drugs 89.6% (87.8-91.5) and antiasthmatics 87.4% (85.4-89.5) were higher than for painkillers 80.0% (77.5-82.4) and contraceptive pills 76.2% (72.3-80.1).
Validity of self-reported previous medication use among adolescents differed by the therapeutic classes of medication. The highest sensitivity was observed for contraceptive pills and lowest for prescribed painkillers.
关于青少年自我报告用药情况的验证性研究一直很少。本研究的目的是以处方数据库作为参考标准，评估青少年自我报告用药情况的敏感性和特异性。
研究人群包括2004年和2005年挪威青少年健康调查中2613名15 - 16岁的青少年队列。将自我报告的用药数据与挪威处方数据库的数据进行比较，该数据库包含挪威药房所有处方的信息。
自我报告用药问题的敏感性方面，避孕药最高，为99.2%（95%置信区间97.7 - 100），相比之下，抗哮喘药为79.1%（66.9 - 91.2），止痛药为48.5%（36.7 - 60.4），精神药物为75.0%（35.6 - 95.6）。精神药物自我报告信息的特异性值为89.6%（87.8 - 91.5），抗哮喘药为87.4%（85.4 - 89.5），高于止痛药的80.0%（77.5 - 82.4）和避孕药的76.2%（72.3 - 80.1）。
青少年自我报告既往用药情况的有效性因药物治疗类别而异。避孕药的敏感性最高，而处方止痛药的敏感性最低。
