趋化因子与神经调节。

Chemokines and neuromodulation.

作者信息

Mélik-Parsadaniantz Stéphane, Rostène William

机构信息

Unité mixte 732 INSERM, UPMC Paris 06, Hôpital Saint-Antoine, Paris, France.

出版信息

J Neuroimmunol. 2008 Jul 31;198(1-2):62-8. doi: 10.1016/j.jneuroim.2008.04.022. Epub 2008 Jun 9.

DOI:10.1016/j.jneuroim.2008.04.022

PMID:18538863

Abstract

Chemokines are not only mediators of the immune system and expressed in inflammatory situations. They are also constitutively expressed in the brain in both glial cells and neurons. Several recent evidence suggest that they can have a neurotransmitter/neuromodulatory role on brain functions similar to several neuropeptides reported so far. The aim of this short review is to illustrate that point using two chemokine systems, SDF-1/CXCL12 and its receptor CXCR4 and MCP-1/CCL2 and its receptor CCR2.

摘要

趋化因子不仅是免疫系统的介质，在炎症情况下表达。它们也在大脑中的神经胶质细胞和神经元中组成性表达。最近的一些证据表明，它们对大脑功能可能具有类似于目前报道的几种神经肽的神经递质/神经调节作用。这篇简短综述的目的是使用两种趋化因子系统，即基质细胞衍生因子-1/CXCL12及其受体CXCR4和单核细胞趋化蛋白-1/CCL2及其受体CCR2来说明这一点。