Buoli Massimiliano, Dozio Elena, Caldiroli Lara, Armelloni Silvia, Vianello Elena, Corsi Romanelli Massimiliano, Castellano Giuseppe, Vettoretti Simone
Department of Neurosciences and Mental Health, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy.
Department of Pathophysiology and Transplantation, Università degli Studi di Milano, 20122 Milan, Italy.
Geriatrics (Basel). 2024 Jul 30;9(4):99. doi: 10.3390/geriatrics9040099.
Depressive disorders are highly prevalent among subjects suffering from chronic kidney disease (CKD). The aim of the present study is to evaluate clinical and biochemical factors associated with depressive disorders in a sample of older CKD patients, with a focus on advanced glycation end products (AGEs) and their soluble receptors (sRAGEs). A total of 115 older subjects affected by CKD (stages 3 to 5, not in dialysis) were selected for this study. These patients were divided into two groups according to the presence of depressive disorders defined by a score ≥ 10 on the 30-item Geriatric Depression Scale (GDS). The two groups were compared by independent sample t tests for continuous variables and χ tests for qualitative ones. Significant variables at univariate analyses were then inserted as predictors of a binary logistic regression model, with the presence or absence of depressive disorders as a dependent variable. The binary logistic regression model showed that patients with concomitant depressive disorders were more frequently of female gender ( < 0.01) and had lower MCP1 ( < 0.01) and AGE circulating levels ( < 0.01) than their counterparts. Depressive disorders in older CKD patients are more prevalent in women and seem to be inversely associated with systemic inflammation and circulating AGEs.
抑郁症在慢性肾脏病（CKD）患者中极为普遍。本研究旨在评估老年CKD患者样本中与抑郁症相关的临床和生化因素，重点关注晚期糖基化终产物（AGEs）及其可溶性受体（sRAGEs）。本研究共选取了115名受CKD影响的老年受试者（3至5期，未进行透析）。根据老年抑郁量表（GDS）30项得分≥10定义的抑郁症存在情况，将这些患者分为两组。连续变量采用独立样本t检验，定性变量采用χ检验对两组进行比较。单因素分析中有统计学意义的变量随后作为二元逻辑回归模型的预测因子，以是否存在抑郁症作为因变量。二元逻辑回归模型显示，伴有抑郁症的患者相比其对照组更常为女性（P<0.01），且MCP1水平（P<0.01）和循环AGE水平（P<0.01）更低。老年CKD患者中的抑郁症在女性中更为普遍，且似乎与全身炎症和循环AGEs呈负相关。
