Rohlman Diane S, Lucchini Roberto, Anger W Kent, Bellinger David C, van Thriel Christoph
Center for Research on Occupational and Environmental Toxicology, L606, Oregon Health & Science University, Portland, OR 97239, USA.
Neurotoxicology. 2008 May;29(3):556-67. doi: 10.1016/j.neuro.2008.04.003. Epub 2008 Apr 18.
Neurobehavioral tests are being increasingly used in human risk assessment and there is a strong need for guidance. The field of neurobehavioral toxicology has evolved from research which initially focused on using traditional neuropsychological tests to identify "abnormal cases" to include methods used to detect sub-clinical deficits, to further incorporate the use of neurosensory assessment, and to expand testing from occupational populations to vulnerable populations including older adults and children. Even as exposures in the workplace are reduced, they have been increasing in the environment and research on exposure has now expanded to cross the entire lifetime. These neurobehavioral methods are applied in research and the findings used for regulatory purposes to develop preventative action for exposed populations. This paper reflects a summary of the talks presented at the Neurobehavioral Testing in Human Risk Assessment symposium presented at the 11th meeting of the International Neurotoxicology Association.
神经行为测试在人类风险评估中的应用越来越广泛，因此迫切需要相关指导。神经行为毒理学领域已从最初专注于使用传统神经心理学测试来识别“异常病例”的研究发展而来，如今已涵盖用于检测亚临床缺陷的方法，进一步纳入了神经感觉评估的应用，并将测试对象从职业人群扩展到包括老年人和儿童在内的弱势群体。即便工作场所的暴露量有所减少，但环境中的暴露量却在增加，目前关于暴露的研究已扩展至整个人生阶段。这些神经行为方法应用于研究中，其结果被用于监管目的，以便为受暴露人群制定预防措施。本文是在国际神经毒理学协会第11次会议上举办的“人类风险评估中的神经行为测试”研讨会上所发表演讲的内容总结。
