Oehm Sebastian, Gilbert David, Tauch Andreas, Stoye Jens, Goesmann Alexander
Center for Biotechnology (CeBiTec), Bielefeld University, D-33594 Bielefeld, Germany.
Nucleic Acids Res. 2008 Jul 1;36(Web Server issue):W433-7. doi: 10.1093/nar/gkn284. Epub 2008 Jun 6.
In order to understand the phenotype of any living system, it is essential to not only investigate its genes, but also the specific metabolic pathway variant of the organism of interest, ideally in comparison with other organisms. The Comparative Pathway Analyzer, CPA, calculates and displays the differences in metabolic reaction content between two sets of organisms. Because results are highly dependent on the distribution of organisms into these two sets and the appropriate definition of these sets often is not easy, we provide hierarchical clustering methods for the identification of significant groupings. CPA also visualizes the reaction content of several organisms simultaneously allowing easy comparison. Reaction annotation data and maps for visualizing the results are taken from the KEGG database. Additionally, users can upload their own annotation data. This website is free and open to all users and there is no login requirement. It is available at https://www.cebitec.uni-bielefeld.de/groups/brf/software/cpa/index.html.
为了了解任何生命系统的表型，不仅要研究其基因，还要研究目标生物体的特定代谢途径变体，理想情况下是与其他生物体进行比较。比较途径分析器（Comparative Pathway Analyzer，CPA）可计算并显示两组生物体之间代谢反应内容的差异。由于结果高度依赖于生物体在这两组中的分布，而对这两组的恰当定义往往并不容易，因此我们提供了层次聚类方法来识别显著的分组。CPA还能同时可视化多个生物体的反应内容，便于进行比较。用于可视化结果的反应注释数据和图谱取自KEGG数据库。此外，用户可以上传自己的注释数据。该网站免费向所有用户开放，无需登录。网址为https://www.cebitec.uni-bielefeld.de/groups/brf/software/cpa/index.html 。
