Jiménez E, Fernández L, Maldonado A, Martín R, Olivares M, Xaus J, Rodríguez J M
Departamento de Nutrición, Bromatología y Tecnología de los Alimentos, Universidad Complutense de Madrid, 28040 Madrid, Spain.
Appl Environ Microbiol. 2008 Aug;74(15):4650-5. doi: 10.1128/AEM.02599-07. Epub 2008 Jun 6.
In this study, 20 women with staphylococcal mastitis were randomly divided in two groups. Those in the probiotic group daily ingested 10 log(10) CFU of Lactobacillus salivarius CECT5713 and the same quantity of Lactobacillus gasseri CECT5714 for 4 weeks, while those in the control one only ingested the excipient. Both lactobacillus strains were originally isolated from breast milk. On day 0, the mean staphylococcal counts in the probiotic and control groups were similar (4.74 and 4.81 log(10) CFU/ml, respectively), but lactobacilli could not be detected. On day 30, the mean staphylococcal count in the probiotic group (2.96 log(10) CFU/ml) was lower than that of the control group (4.79 log(10) CFU/ml). L. salivarius CECT5713 and L. gasseri CECT5714 were isolated from the milk samples of 6 of the 10 women of the probiotic group. At day 14, no clinical signs of mastitis were observed in the women assigned to the probiotic group, but mastitis persisted throughout the study period in the control group women. In conclusion, L. salivarius CECT5713 and L. gasseri CECT5714 appear to be an efficient alternative for the treatment of lactational infectious mastitis during lactation.
在本研究中，20名患有葡萄球菌性乳腺炎的女性被随机分为两组。益生菌组的女性每天摄入10 log(10) CFU的唾液乳杆菌CECT5713和等量的加氏乳杆菌CECT5714，持续4周，而对照组的女性只摄入赋形剂。这两种乳杆菌菌株最初均从母乳中分离得到。在第0天，益生菌组和对照组的葡萄球菌平均计数相似（分别为4.74和4.81 log(10) CFU/ml），但未检测到乳杆菌。在第30天，益生菌组的葡萄球菌平均计数（2.96 log(10) CFU/ml）低于对照组（4.79 log(10) CFU/ml）。从益生菌组10名女性中的6名的乳汁样本中分离出了唾液乳杆菌CECT5713和加氏乳杆菌CECT5714。在第14天，分配到益生菌组的女性未观察到乳腺炎的临床症状，但对照组的女性在整个研究期间乳腺炎持续存在。总之，唾液乳杆菌CECT5713和加氏乳杆菌CECT5714似乎是哺乳期治疗哺乳期感染性乳腺炎的一种有效替代方法。
