Jenkins C C, DeNovo R C, Patton C S, Bright R M, Rohrbach B W
Department of Urban Practice, College of Veterinary Medicine, University of Tennessee, Knoxville 37901-1071.
Am J Vet Res. 1991 May;52(5):658-61.
A double-blind study was conducted to compare gastric ulcer healing time in nontreated dogs with that in dogs treated with either cimetidine or omeprazole. Single ulcers were created in the gastric antrum by use of a suction biopsy capsule. Each dog was given 25 mg of aspirin/kg of body weight orally for 20 days after ulcer induction. Five control dogs were given aspirin only (no anti-ulcer medication) during the 20-day study. Six dogs were given cimetidine at dosage of 10 mg/kg orally every 8 hours, and 6 dogs were given omeprazole orally at dosage of 2 mumol/kg (0.7 mg/kg) once daily. All dogs were examined endoscopically on days 5, 10, 15, and 20 and were given a score for the size of the mechanically created ulcer and a score for the degree of aspirin-induced gastritis. All dogs were euthanatized on day 21, and gastric lesions were examined histologically. Significant differences were not evident in ulcer healing scores or degree of aspirin-induced gastritis among treated and nontreated dogs on days 5, 10, 15, and 20. However, aspirin-induced gastritis was less severe in dogs of the omeprazole group than in dogs of the cimetidine or control group on each day observations were made. The effect of omeprazole given once daily was comparable with that of cimetidine given every 8 hours in lessening aspirin-induced gastritis.
进行了一项双盲研究，以比较未治疗犬与接受西咪替丁或奥美拉唑治疗的犬的胃溃疡愈合时间。通过使用抽吸活检胶囊在胃窦中制造单个溃疡。在诱导溃疡后，每只犬口服25mg/kg体重的阿司匹林，持续20天。在为期20天的研究中，5只对照犬仅给予阿司匹林（无抗溃疡药物）。6只犬每8小时口服10mg/kg剂量的西咪替丁，6只犬每天口服2μmol/kg（0.7mg/kg）剂量的奥美拉唑。在第5、10、15和20天对所有犬进行内镜检查，并对机械性溃疡的大小和阿司匹林诱导的胃炎程度进行评分。所有犬在第21天实施安乐死，并对胃部病变进行组织学检查。在第5、10、15和20天，治疗组和未治疗组犬的溃疡愈合评分或阿司匹林诱导的胃炎程度没有明显差异。然而，在每次进行观察的日子里，奥美拉唑组犬的阿司匹林诱导的胃炎比西咪替丁组或对照组犬的要轻。每天给予一次奥美拉唑在减轻阿司匹林诱导的胃炎方面的效果与每8小时给予一次西咪替丁的效果相当。
