仓鼠BHK - 21 - C13细胞中的多瘤病毒基因组：整合到细胞DNA并诱导病毒复制。
Polyoma genome in hamster BHK-21-C13 cells: integration into cellular DNA and induction of the viral replication.
作者信息
Folk W R, Bancuk J E
出版信息
J Virol. 1976 Oct;20(1):133-41. doi: 10.1128/JVI.20.1.133-141.1976.
Abstract
When grown at 39.5 degrees C, BHK-21 C-13 cells transformed by A gene mutants of polyoma virus contain viral sequences that are predominantly associated with cellular DNA pelleted in the Hirt lysis procedure. At this temperature, in cells that are inducible for viral DNA replication (Folk, 1973), the majority of the viral genomes are covalently joined with cellular DNA's containing repetitious sequences. Upon a shift to 31 degrees C, free viral genomes appear and are replicated. Coupled with the replication of the free viral genomes at 31 degrees C is an increase in the viral genomes associated with cellular DNA.
摘要
当在39.5摄氏度下培养时，被多瘤病毒A基因变异体转化的BHK - 21 C - 13细胞含有主要与在Hirt裂解过程中沉淀的细胞DNA相关的病毒序列。在此温度下，在可诱导病毒DNA复制的细胞中（Folk，1973），大多数病毒基因组与含有重复序列的细胞DNA共价连接。当温度转移到31摄氏度时，游离病毒基因组出现并进行复制。在31摄氏度下，游离病毒基因组的复制伴随着与细胞DNA相关的病毒基因组数量的增加。
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