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1
Integration of deoxyribonucleic acid specific for Rous sarcoma virus after infection of permissive and nonpermissive hosts.劳斯肉瘤病毒特异性脱氧核糖核酸在允许性宿主和非允许性宿主感染后的整合。
Proc Natl Acad Sci U S A. 1973 Nov;70(11):3067-71. doi: 10.1073/pnas.70.11.3067.
2
Appearance of virus-specific DNA in mammalian cells following transformation by Rous sarcoma virus.劳氏肉瘤病毒转化后哺乳动物细胞中病毒特异性DNA的出现。
J Mol Biol. 1973 Mar 15;74(4):613-26. doi: 10.1016/0022-2836(73)90052-1.
3
The classic: integration of deoxyribonucleic acid specific for Rous sarcoma virus after infection of permissive and nonpermissive hosts: (RNA tumor viruses/reassociation kinetics/duck cells). 1973.经典文献：劳斯肉瘤病毒特异性脱氧核糖核酸在允许宿主和非允许宿主感染后的整合：（RNA肿瘤病毒/重缔合动力学/鸭细胞）。1973年
Clin Orthop Relat Res. 2008 Sep;466(9):2031-8. doi: 10.1007/s11999-008-0355-8. Epub 2008 Jul 3.
4
Variations in integration site of avian oncornaviruses in different hosts.禽肿瘤病毒在不同宿主中整合位点的变异。
J Virol. 1977 Feb;21(2):541-7. doi: 10.1128/JVI.21.2.541-547.1977.
5
Deoxyribonucleic acid polymerase of Rous sarcoma virus: studies on the mechanism of double-stranded deoxyribonucleic acid synthesis.劳氏肉瘤病毒的脱氧核糖核酸聚合酶：双链脱氧核糖核酸合成机制的研究
J Virol. 1971 May;7(5):539-48. doi: 10.1128/JVI.7.5.539-548.1971.
6
Early synthesis of virus-specific RNA and DNA in cells rapidly transformed with Rous sarcoma virus.用劳氏肉瘤病毒快速转化的细胞中病毒特异性RNA和DNA的早期合成。
Virology. 1973 Dec;56(2):532-48. doi: 10.1016/0042-6822(73)90056-1.
7
Transcription of the Rous sarcoma virus genome in vitro and in vivo.劳氏肉瘤病毒基因组在体外和体内的转录
Bibl Haematol. 1975(40):517-23. doi: 10.1159/000397569.
8
Use of alkaline sucrose gradients in a zonal rotor to detect integrated and unintegrated avian sarcoma virus-specific DNA in cells.利用区域转子中的碱性蔗糖梯度来检测细胞中整合和未整合的禽肉瘤病毒特异性DNA。
J Virol. 1976 May;18(2):574-85. doi: 10.1128/JVI.18.2.574-585.1976.
9
Deoxyribonucleic acid polymerases of Rous sarcoma virus: kinetics of deoxyribonucleic acid synthesis and specificity of the products.劳氏肉瘤病毒的脱氧核糖核酸聚合酶：脱氧核糖核酸合成动力学及产物特异性
J Virol. 1971 Feb;7(2):227-32. doi: 10.1128/JVI.7.2.227-232.1971.
10
Temperature-dependent alterations in sugar transport in cells infected by a temperature-sensitive mutant of Rous sarcoma virus.劳斯肉瘤病毒温度敏感突变体感染的细胞中糖转运的温度依赖性改变。
Proc Natl Acad Sci U S A. 1971 Nov;68(11):2739-41. doi: 10.1073/pnas.68.11.2739.

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How Chaotic Is Genome Chaos?基因组的混乱程度究竟如何？
Cancers (Basel). 2021 Mar 17;13(6):1358. doi: 10.3390/cancers13061358.
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Gene therapy: progress and predictions.基因治疗：进展与预测。
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The road to HIV-1 integrase inhibitors: the case for supporting basic research.通往HIV-1整合酶抑制剂之路：支持基础研究的理由
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Organ explant culture of neonatal rat ventricles: a new model to study gene and cell therapy.新生大鼠心室器官外植培养：一种研究基因和细胞治疗的新模型。
PLoS One. 2013;8(3):e59290. doi: 10.1371/journal.pone.0059290. Epub 2013 Mar 13.
5
Properties of cells carrying the herpes simplex virus type 2 thymidine kinase gene: mechanisms of reversion to a thymidine kinase-negative phenotype.携带单纯疱疹病毒2型胸苷激酶基因的细胞特性：回复为胸苷激酶阴性表型的机制
J Virol. 1980 Dec;36(3):746-55. doi: 10.1128/JVI.36.3.746-755.1980.
6
Sequence arrangement in satellite DNA from the muskmelon.甜瓜卫星DNA中的序列排列
Plant Physiol. 1977 Apr;59(4):604-9. doi: 10.1104/pp.59.4.604.
7
Quantitative correlation of homogeneously stained regions on chromosome 10 with dihydrofolate reductase enzyme in human cells.人类细胞中10号染色体上均匀染色区域与二氢叶酸还原酶的定量相关性。
Proc Natl Acad Sci U S A. 1983 Feb;80(3):807-9. doi: 10.1073/pnas.80.3.807.
8
Hematopoietic cell transformation by a murine recombinant retrovirus containing the src gene of Rous sarcoma virus.含有劳氏肉瘤病毒src基因的鼠重组逆转录病毒对造血细胞的转化
Proc Natl Acad Sci U S A. 1984 Apr;81(8):2374-8. doi: 10.1073/pnas.81.8.2374.
9
Construction and isolation of a transforming murine retrovirus containing the src gene of Rous sarcoma virus.含有劳氏肉瘤病毒src基因的转化型鼠逆转录病毒的构建与分离。
J Virol. 1983 May;46(2):594-605. doi: 10.1128/JVI.46.2.594-605.1983.
10
Covalently closed circular DNAs of murine type C retrovirus: depressed formation in cells treated with cycloheximide early after infection.鼠C型逆转录病毒的共价闭合环状DNA：感染后早期用环己酰亚胺处理的细胞中其形成受到抑制。
J Virol. 1980 Oct;36(1):181-8. doi: 10.1128/JVI.36.1.181-188.1980.

本文引用的文献

1
Demonstration of the absence of infectious Rous virus in rat tumour XC, whose structurally intact cells produce Rous sarcoma when transferred to chicks.在大鼠肿瘤XC中未检测到传染性劳氏病毒，该肿瘤结构完整的细胞转移至雏鸡时会产生劳氏肉瘤。
Folia Biol (Praha). 1963 Apr;9:77-81.
2
Repeated sequences in DNA. Hundreds of thousands of copies of DNA sequences have been incorporated into the genomes of higher organisms.DNA中的重复序列。数以十万计的DNA序列拷贝已被纳入高等生物的基因组中。
Science. 1968 Aug 9;161(3841):529-40. doi: 10.1126/science.161.3841.529.
3
Reiteration frequency of duck haemoglobin genes.鸭血红蛋白基因的重复频率。
Nat New Biol. 1973 Feb 14;241(111):204-7. doi: 10.1038/newbio241204a0.
4
Envelope classification of avian RNA tumor viruses.禽RNA肿瘤病毒的包膜分类
Bibl Haematol. 1970(36):153-67. doi: 10.1159/000391704.
5
Mechanism of cell transformation by RNA tumor viruses.RNA肿瘤病毒导致细胞转化的机制。
Annu Rev Microbiol. 1971;25:609-48. doi: 10.1146/annurev.mi.25.100171.003141.
6
The RNA tumor viruses--background and foreground.RNA肿瘤病毒——背景与前景
Proc Natl Acad Sci U S A. 1972 Apr;69(4):1016-20. doi: 10.1073/pnas.69.4.1016.
7
Detection of avian tumor virus-specific nucleotide sequences in avian cell DNAs (reassociation kinetics-RNA tumor viruses-gas antigen-Rous sarcoma virus, chick cells).在禽细胞DNA中检测禽肿瘤病毒特异性核苷酸序列（重缔合动力学- RNA肿瘤病毒-气体抗原-劳氏肉瘤病毒，鸡细胞）
Proc Natl Acad Sci U S A. 1972 Jan;69(1):20-4. doi: 10.1073/pnas.69.1.20.
8
Cytoplasmic DNA synthesis induced by RNA tumor viruses.RNA肿瘤病毒诱导的细胞质DNA合成。
Proc Natl Acad Sci U S A. 1971 Aug;68(8):1844-7. doi: 10.1073/pnas.68.8.1844.
9
Extent of transcription by the RNA-dependent DNA polymerase of Rous sarcoma virus.劳氏肉瘤病毒的RNA依赖性DNA聚合酶的转录范围。
Nat New Biol. 1971 Sep 1;233(35):19-21. doi: 10.1038/newbio233019a0.
10
Quantitation of Simian virus 40 sequences in African green monkey, mouse and virus-transformed cell genomes.非洲绿猴、小鼠及病毒转化细胞基因组中猿猴病毒40序列的定量分析。
J Mol Biol. 1971 Apr 14;57(1):129-45. doi: 10.1016/0022-2836(71)90123-9.

劳斯肉瘤病毒特异性脱氧核糖核酸在允许性宿主和非允许性宿主感染后的整合。

Integration of deoxyribonucleic acid specific for Rous sarcoma virus after infection of permissive and nonpermissive hosts.

作者信息

Varmus H E, Vogt P K, Bishop J M

出版信息

Proc Natl Acad Sci U S A. 1973 Nov;70(11):3067-71. doi: 10.1073/pnas.70.11.3067.

DOI:10.1073/pnas.70.11.3067
PMID:4361674
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC427171/
Abstract

A relatively simple but stringent technique was developed to detect the integration of virus-specific DNA into the genomes of higher organisms. In both permissive (duck) and nonpermissive (mammalian) cells which normally contain no nucleotide sequences specific for Rous sarcoma virus, transformation by the virus results in the appearance of DNA specific for Rous sarcoma virus covalently integrated into strands of host-cell DNA containing reiterated sequences. Early after infection of mouse or duck cells by Rous sarcoma virus, unintegrated DNA specific for the virus can be demonstrated.

摘要

人们开发出了一种相对简单但严格的技术，用于检测病毒特异性DNA整合到高等生物基因组中的情况。在通常不含有罗氏肉瘤病毒特异性核苷酸序列的允许性（鸭）细胞和非允许性（哺乳动物）细胞中，该病毒诱导的转化都会导致罗氏肉瘤病毒特异性DNA出现，这些DNA共价整合到含有重复序列的宿主细胞DNA链中。在罗氏肉瘤病毒感染小鼠或鸭细胞后不久，就能检测到病毒的未整合特异性DNA。