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Id基因可被血清激活，但在大鼠血管平滑肌细胞去分化过程中并非必需。

The Id gene is activated by serum but is not required for de-differentiation in rat vascular smooth muscle cells.

作者信息

Kemp P R, Grainger D J, Shanahan C M, Weissberg P L, Metcalfe J C

机构信息

Department of Biochemistry, University of Cambridge, U.K.

出版信息

Biochem J. 1991 Jul 1;277 ( Pt 1)(Pt 1):285-8. doi: 10.1042/bj2770285.

DOI:10.1042/bj2770285
PMID:1854341
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1151222/
Abstract

Primary rat vascular smooth muscle cells cultured on fibronectin in the absence of serum lost smooth-muscle-specific myosin heavy chain but did not enter the cell cycle and proliferate until they were stimulated by serum. Under these conditions accumulation of Id mRNA occurred only in response to serum and was maximal during the G1 phase of the cycle.

摘要

在无血清条件下于纤连蛋白上培养的原代大鼠血管平滑肌细胞失去了平滑肌特异性肌球蛋白重链，但在受到血清刺激之前不会进入细胞周期并增殖。在这些条件下，Id mRNA的积累仅在对血清作出反应时发生，并且在细胞周期的G1期达到最大值。

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Smooth muscle phenotypic expression in human carotid arteries. I. Comparison of cells from diffuse intimal thickenings adjacent to atheromatous plaques with those of the media.人类颈动脉中的平滑肌表型表达。I. 动脉粥样硬化斑块附近弥漫性内膜增厚处的细胞与中膜细胞的比较。
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