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大鼠主动脉内膜增厚、人动脉粥样硬化斑块及培养的大鼠主动脉中膜平滑肌细胞中的肌动蛋白表达。

Actin expression in smooth muscle cells of rat aortic intimal thickening, human atheromatous plaque, and cultured rat aortic media.

作者信息

Gabbiani G, Kocher O, Bloom W S, Vandekerckhove J, Weber K

出版信息

J Clin Invest. 1984 Jan;73(1):148-52. doi: 10.1172/JCI111185.

DOI:10.1172/JCI111185
PMID:6690475
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC424985/
Abstract

Actin of smooth muscle cells of rat and human aortic media shows a predominance of the alpha-isoform. In experimental rat aortic intimal thickening, in human atheromatous plaque, and in cultured aortic smooth muscle cells, there is a typical switch in actin expression with a predominance of the beta-form and a noticeable amount of gamma-form. This pattern of actin expression represents a new reliable protein-chemical marker of experimental and human atheromatous smooth muscle cells.

摘要

大鼠和人主动脉中膜平滑肌细胞的肌动蛋白以α-异构体为主。在实验性大鼠主动脉内膜增厚、人类动脉粥样硬化斑块以及培养的主动脉平滑肌细胞中，肌动蛋白表达出现典型转变，以β-型为主且有显著量的γ-型。这种肌动蛋白表达模式代表了实验性和人类动脉粥样硬化平滑肌细胞一种新的可靠的蛋白质化学标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87f5/424985/efbe30c796c5/jcinvest00129-0161-b.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87f5/424985/5d9ceda6870c/jcinvest00129-0160-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87f5/424985/276223ab24c4/jcinvest00129-0160-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87f5/424985/e44dc7420403/jcinvest00129-0160-d.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87f5/424985/efbe30c796c5/jcinvest00129-0161-b.jpg

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