Kung Chien-Min, Wang Hai-Lung, Tseng Zu-Lin
Department of Medical Laboratory Science and Biotechnology, College of Biomedical Science and Technology, Yuanpei University, Hsinchu, Taiwan, Republic of China.
Clin Invest Med. 2008;31(3):E138-49. doi: 10.25011/cim.v31i3.3471.
To examines the hypothesis that smoking exacerbates health problems in young male smokers (age range, 18.6-22.8 yr; mean, 19.4 yr).
1169 subjects were recruited, 25.41 % were smokers (2-15 cigarettes daily). All subjects were examined for body mass index, blood pressure, exhaled carbon monoxide content (carboxyl hemoglobin), blood hematology and biochemistry.
Data for WBC (P < 0.001), hemoglobin (P=0.001), hematocrit (P=0.004), MCV (P=0.001), MCH (P=0.003), COHB% (P < 0.001), albumin/globulin (P < 0.001) and triglyceride (P < 0.001) were higher for smokers than non-smokers, while total-bilirubin (P < 0.001), total protein (P < 0.001) and globulin (P < 0.001) were markedly lower. The results of WBC (r=0.164, P < 0.004), COHB% (r=0.958, P < 0.001), gamma glutamyl transpeptidase (r=0.159, P=0.006), alkaline-phosphatase (r=-0.154, P=0.008) and triglyceride (r=0.144, P < 0.001) were closely correlated with number of cigarettes smoked daily. Investigation of associations with illness revealed that young smokers had an increased risk of hypertriglyceridemia to young non-smokers (adjusted ORs, 2.124; 95% CIs, 1.414-3.190), hyperglycemia (adjusted ORs, 1.980; 95% CIs, 0.803-4.901), neutrophilia (adjusted ORs, 1.947; 95% CIs, 1.248-3.037), RBC macrocytosis (adjusted ORs, 1.929; 95% CIs, 1.137-3.275), hyperchromia (adjusted ORs, 1.844; 95% CIs, 1.412-2.407) and polycythemia (adjusted ORs, 1.314; 95% CIs, 0.805-2.145) (all P < 0.05 for linear trends).
The findings emphasize the importance of increasing surveillance of diseases exacerbated by smoking and reducing smoking in the young to prevent cardiovascular illnesses, metabolite disorders and other clinical diseases.
检验吸烟会加重年轻男性吸烟者（年龄范围18.6 - 22.8岁；平均19.4岁）健康问题这一假设。
招募了1169名受试者，25.41%为吸烟者（每日吸烟2 - 15支）。对所有受试者进行体重指数、血压、呼出一氧化碳含量（羧基血红蛋白）、血液血液学和生物化学检查。
吸烟者的白细胞（P < 0.001）、血红蛋白（P = 0.001）、红细胞压积（P = 0.004）、平均红细胞体积（P = 0.001）、平均红细胞血红蛋白含量（P = 0.003）、碳氧血红蛋白百分比（P < 0.001）、白蛋白/球蛋白（P < 0.001）和甘油三酯（P < 0.001）高于非吸烟者，而总胆红素（P < 0.001）、总蛋白（P < 0.001）和球蛋白（P < 0.001）则显著较低。白细胞（r = 0.164，P < 0.004）、碳氧血红蛋白百分比（r = 0.958，P < 0.001）、γ-谷氨酰转肽酶（r = 0.159，P = 0.006）、碱性磷酸酶（r = -0.154，P = 0.008）和甘油三酯（r = 0.144，P < 0.001）的结果与每日吸烟量密切相关。与疾病关联的调查显示，年轻吸烟者患高甘油三酯血症的风险高于年轻非吸烟者（调整后的比值比，2.124；95%置信区间，1.414 - 3.190）、高血糖（调整后的比值比，1.980；95%置信区间，0.803 - 4.901）、中性粒细胞增多（调整后的比值比，1.947；95%置信区间，1.248 - 3.037）、红细胞大细胞性（调整后的比值比，1.929；95%置信区间，1.137 - 3.275）、高色素血症（调整后的比值比，1.844；95%置信区间，1.412 - 2.407）和红细胞增多症（调整后的比值比，1.314；95%置信区间，0.805 - 2.145）（所有线性趋势的P < 0.05）。
研究结果强调了加强对吸烟加剧疾病的监测以及减少年轻人吸烟以预防心血管疾病、代谢紊乱和其他临床疾病的重要性。
