Department of Occupational Medicine, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan.
Division of Gastroenterology and Hepatology, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan.
J Clin Lab Anal. 2019 Sep;33(7):e22946. doi: 10.1002/jcla.22946. Epub 2019 Jun 26.
Increasing evidence suggests an association between lifestyle and white blood cell (WBC) count; however, no study has examined the effects of lifestyle associations on hematological parameters. The aim of this study was to examine the association between lifestyle factors and hematological parameters in a large population-based sample of Chinese male steelworkers.
This study included 3189 male workers at a steel plant who responded to a cross-sectional questionnaire on basic attributes, lifestyle, and sleep. All workers in the plant underwent periodic health checkups. Hematological parameters were also examined at the checkup.
Stepwise linear regression analyses showed that smoking, poor sleep, shift work, and obesity were all significant factors associated with WBC count. Obesity was independently associated with RBC count. Furthermore, smoking and obesity were associated with hemoglobin, and smoking, poor sleep, and obesity were independently associated with hematocrit. Moreover, smoking was the main factor associated with MCV and MCH. When the subjects were divided into quartiles according to WBC count, RBC count, hemoglobin, hematocrit, MCV, MCH, and increased WBC count were associated with smoking, poor sleep, shift work, and obesity. Increased hemoglobin was associated with smoking and obesity. Furthermore, an increased RBC count was associated with obesity, and increased hematocrit was associated with smoking, poor sleep, and obesity. Similarly, increased MCV and MCH were also associated with smoking.
This study indicates that lifestyle factors may exert an important effect on hematological parameters (eg, WBC count, RBC count, hemoglobin, hematocrit, MCV, and MCH).
越来越多的证据表明生活方式与白细胞（WBC）计数之间存在关联；然而，尚无研究探讨生活方式关联对血液学参数的影响。本研究旨在检验生活方式因素与中国男性钢铁工人大型人群样本中血液学参数之间的关联。
本研究纳入了一家钢铁厂的 3189 名男性工人，他们对一份关于基本属性、生活方式和睡眠的横断面问卷做出了回应。该工厂的所有工人都接受了定期健康检查。在体检时还检查了血液学参数。
逐步线性回归分析表明，吸烟、睡眠质量差、轮班工作和肥胖均与 WBC 计数显著相关。肥胖与 RBC 计数独立相关。此外，吸烟和肥胖与血红蛋白相关，而吸烟、睡眠质量差和肥胖与血细胞比容独立相关。此外，吸烟是与 MCV 和 MCH 相关的主要因素。当根据 WBC 计数、RBC 计数、血红蛋白、血细胞比容、MCV、MCH 和白细胞增多将受试者分为四分位数时，白细胞增多、RBC 计数、血红蛋白、血细胞比容、MCV 和 MCH 与吸烟、睡眠质量差、轮班工作和肥胖相关。血红蛋白增加与吸烟和肥胖有关。此外，RBC 计数增加与肥胖有关，血细胞比容增加与吸烟、睡眠质量差和肥胖有关。同样，MCV 和 MCH 增加也与吸烟有关。
本研究表明，生活方式因素可能对血液学参数（如 WBC 计数、RBC 计数、血红蛋白、血细胞比容、MCV 和 MCH）产生重要影响。
