Social Determinants of Health Research Center, Birjand University of Medical Sciences, Birjand, Iran.
Social Determinants of Health Research Center, Department of Health Promotion and Education, School of Health, Birjand University of Medical Sciences, Birjand, Iran.
Biomed Res Int. 2023 Feb 21;2023:4683542. doi: 10.1155/2023/4683542. eCollection 2023.
Cigarette smoking is a significant risk factor for chronic and atherosclerotic vascular disease that causes preventable considerable morbidity and mortality worldwide. This study is aimed at comparing inflammation and the levels of oxidative stress biomarkers in elderly subjects. The authors recruited the participants (1281 older adults) from the Birjand Longitudinal of Aging study. They measured oxidative stress and inflammatory biomarkers serum levels in the 101 cigarettes and 1180 nonsmokers. The mean age of smokers was 69.3 ± 7.95 years, and most were male. The most percentage of male cigarette smokers have lower body mass index (BMI) (≤19 kg/m). Females have higher BMI categories than males ( ≤ 0.001). The percentage of diseases and defects was different between cigarette and non-cigarette smoker adults ( ≤ 0.01 to ≤ 0.001). The total white blood cells, neutrophils, and eosinophils were significantly higher in cigarettes compared to non-cigarette smokers ( ≤ 0.001). Besides, cigarette consumers' percentage of hemoglobin and hematocrit compared to other aged people was significantly different ( ≤ 0.001). However, biomarkers of oxidative stress and antioxidant levels were not significant differences between the two senior groups. Cigarette smoking in older adults was associated with increased inflammatory biomarkers and cells, but it did not find a significant difference in oxidative stress markers. Longitudinal prospective studies may help illuminate the mechanisms inducing oxidative stress and inflammation due to cigarette smoking in each gender.
吸烟是导致慢性和动脉粥样硬化血管疾病的重要危险因素，在全球范围内造成了可预防的大量发病和死亡。本研究旨在比较老年人的炎症和氧化应激生物标志物水平。作者从比詹德老龄化纵向研究中招募了参与者（1281 名老年人）。他们测量了 101 名吸烟者和 1180 名不吸烟者的血清氧化应激和炎症生物标志物水平。吸烟者的平均年龄为 69.3 ± 7.95 岁，大多数为男性。大多数男性吸烟者的身体质量指数（BMI）较低（≤19kg/m）。女性的 BMI 类别高于男性（≤0.001）。吸烟和不吸烟的成年人之间的疾病和缺陷百分比不同（≤0.01 至≤0.001）。与不吸烟者相比，吸烟者的总白细胞、中性粒细胞和嗜酸性粒细胞显著升高（≤0.001）。此外，与其他老年人相比，吸烟者的血红蛋白和血细胞比容百分比差异显著（≤0.001）。然而，两组老年人的氧化应激和抗氧化剂水平的生物标志物没有显著差异。老年人吸烟与炎症生物标志物和细胞增加有关，但未发现氧化应激标志物有显著差异。纵向前瞻性研究可能有助于阐明由于吸烟引起的每个性别中氧化应激和炎症的诱导机制。
