Levy Jerrold H, Tanaka Kenichi A
Department of Anesthesiology, Emory University Hospital, 1364 Clifton Road, NE, Atlanta, GA 30322, USA.
Vascular. 2008 Mar-Apr;16 Suppl 1:S14-21.
Despite improvements in surgical techniques, the risk for perioperative bleeding remains significant. Transfusion of allogeneic red blood cells, platelets, and hemostatic factors remains the mainstay of current therapy strategy for management of perioperative bleeding. Transfusions significantly contribute to perioperative adverse events. Pharmacologic strategies to prevent or decrease perioperative bleeding are also important therapeutic approaches to reduce the need for allogeneic transfusions. This article discusses systemic pharmacologic prohemostatic agents (aprotinin, lysine analogues, protamine, desmopressin, and recombinant factor VIIa).
尽管手术技术有所改进，但围手术期出血风险仍然很高。输注异体红细胞、血小板和止血因子仍然是目前围手术期出血管理治疗策略的主要手段。输血显著增加围手术期不良事件。预防或减少围手术期出血的药物策略也是减少异体输血需求的重要治疗方法。本文讨论全身性药物促凝血剂（抑肽酶、赖氨酸类似物、鱼精蛋白、去氨加压素和重组凝血因子VIIa）。
