Lobene R R, Battista G W, Petrone D M, Volpe A R, Petrone M E
Am J Dent. 1991 Apr;4(2):83-5.
A 6-month, double-blind, parallel and unsupervised clinical study was conducted to compare the effects on supragingival calculus formation of a dentifrice containing 0.3% triclosan and 2.0% of a copolymer in a 0.243% sodium fluoride/silica base, as compared to a placebo dentifrice containing 0.243% sodium fluoride in a silica base. Subjects were initially stratified into two balanced groups based on their Volpe-Manhold calculus index scores that were obtained from a 3-month pre-test period using a placebo dentifrice. All subjects received an oral prophylaxis and were assigned to the use of either the fluoride/triclosan/copolymer dentifrice or the placebo dentifrice. Seventy adult male and female subjects completed the entire 6-month study. The results after 3-months' use of their respective dentifrices indicated that the subjects using the fluoride/triclosan/copolymer dentifrice had 26.34% less supragingival calculus formation than the subjects using the placebo dentifrice. This reduction in supragingival calculus was significant at the 99% level of confidence. The results after 6 months indicated that the subjects using the fluoride/triclosan/copolymer dentifrice had 36.27% less supragingival calculus formation than the subjects using the placebo dentifrice. This reduction was significant at the 99% level of confidence.
进行了一项为期6个月的双盲、平行且无监督的临床研究，以比较一种含0.3%三氯生和2.0%共聚物的牙膏（以0.243%氟化钠/二氧化硅为基质）与一种含0.243%氟化钠的二氧化硅基质安慰剂牙膏对龈上牙石形成的影响。根据受试者在使用安慰剂牙膏进行的为期3个月的预测试期间获得的Volpe-Manhold牙石指数得分，最初将他们分层为两个平衡组。所有受试者均接受了口腔预防治疗，并被分配使用含氟化物/三氯生/共聚物的牙膏或安慰剂牙膏。70名成年男性和女性受试者完成了整个6个月的研究。使用各自牙膏3个月后的结果表明，使用含氟化物/三氯生/共聚物牙膏的受试者龈上牙石形成比使用安慰剂牙膏的受试者少26.34%。在99%的置信水平下，龈上牙石的这种减少具有统计学意义。6个月后的结果表明，使用含氟化物/三氯生/共聚物牙膏的受试者龈上牙石形成比使用安慰剂牙膏的受试者少36.27%。在99%的置信水平下，这种减少具有统计学意义。
