Habib M, Gayraud D, Oliva A, Regis J, Salamon G, Khalil R
Neurological Clinic, C.H.U. Timone, Marseilles, France.
Brain Cogn. 1991 May;16(1):41-61. doi: 10.1016/0278-2626(91)90084-l.
In view of conflicting data in the existing literature, we examined 53 normal subjects using a handedness questionnaire and callosal area measurements obtained from midsagittal MRI images. The callosum was found to be significantly larger in nonconsistent right-handers (NCRH), especially in its anterior half and especially for males. A significant hand x sex interaction, favoring consistent right-handed (CRH) females, was also found for the posterior midbody, a region known to house interhemispheric fibers connecting the right and left posterior association cortices. These results (1) confirm Witelson's (1985) first findings on postmortem specimens; (2) validate a dichotomy between CRH and NCRH rather than simply considering the writing hand, as was the case in most other similar studies; and (3) suggest that at least two different sex-related--probably hormonal--factors may be acting during the callosal development, one explaining the larger anterior half in NCRH males and the other the larger posterior midbody in CRH females.
鉴于现有文献中的数据相互矛盾，我们使用利手问卷和从正中矢状面MRI图像获得的胼胝体面积测量值，对53名正常受试者进行了检查。结果发现，非一致性右利手者（NCRH）的胼胝体明显更大，尤其是在前半部分，男性尤为明显。在胼胝体后中部，也发现了显著的手×性别交互作用，该区域存在连接左右后联合皮质的半球间纤维，这种交互作用有利于一致性右利手（CRH）女性。这些结果（1）证实了威特elson（1985年）对尸检标本的最初发现；（2）验证了CRH和NCRH之间的二分法，而不是像大多数其他类似研究那样简单地考虑书写手；（3）表明至少有两种不同的与性别相关（可能是激素相关）的因素可能在胼胝体发育过程中起作用，一种因素解释了NCRH男性胼胝体前半部分较大的原因，另一种因素解释了CRH女性胼胝体后中部较大的原因。
