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[人类嗜T淋巴细胞病毒1型/2型感染:南马托格罗索州将产前检查作为疾病控制策略的成效]

[HTLV 1/2 infection: prenatal performance as a disease control strategy in State of Mato Grosso do Sul].

作者信息

Dal Fabbro Márcia Maria Ferrairo Janini, Cunha Rivaldo Venâncio da, Bóia Márcio Neves, Portela Patrícia, Botelho Carlos Augusto, Freitas Gisele Maria Brandão de, Soares Joana, Ferri Juliana, Lupion Juliana

机构信息

Instituto de Pesquisas, Ensino e Diagnósticos, Associação de Pais e Amigos dos Excepcionais de Campo Grande, Campo Grande, MS.

出版信息

Rev Soc Bras Med Trop. 2008 Mar-Apr;41(2):148-51. doi: 10.1590/s0037-86822008000200003.

Abstract

In this study, the prevalence of HTLV 1/2 infection among pregnant women in the State of Mato Grosso do Sul was estimated by means of the ELISA, Western Blot and PCR techniques, in blood samples collected by peripheral venous puncture. 116,689 pregnant women were examined and 153 were diagnosed as presenting HTLV 1/2 infection, with prevalence of 0.13%. Among these 153 pregnant women, 133 (86.9%) had type 1 and 20 (11.1%) had type 2; 73.2% were black, brown or indigenous; about 90% performed domestic activities; and 75.8% (116/153) had been to school for seven years or less. The 153 pregnant women had 172 pregnancies during the study period and 164 pregnancies were followed. Out of pregnancies that were followed, 6.7% (11/164) evolved to abortion, 26.8% (41/153) reported previous abortions and 31.7% (13/41) had had more than two abortions. Comorbidities were found in 17% (26/153), among whom 3.3% (5/153) had HIV (p<0.000002). The authors emphasize the importance of identifying pregnant women with HTLV 1/2 infection, as a strategy for disease control and prevention.

摘要

在本研究中,通过酶联免疫吸附测定(ELISA)、蛋白质印迹法和聚合酶链反应(PCR)技术,对南马托格罗索州孕妇外周静脉穿刺采集的血样进行检测,以估算人类嗜T淋巴细胞病毒1型/2型(HTLV 1/2)感染率。共检查了116,689名孕妇,其中153人被诊断为HTLV 1/2感染,感染率为0.13%。在这153名感染孕妇中,133人(86.9%)感染1型,20人(11.1%)感染2型;73.2%为黑人、棕色人种或原住民;约90%从事家务活动;75.8%(116/153)接受学校教育的时间为七年或以下。在研究期间,这153名感染孕妇共有172次妊娠,其中164次妊娠得到随访。在随访的妊娠中,6.7%(11/164)发生流产,26.8%(41/153)报告有既往流产史,31.7%(13/41)有过两次以上流产史。17%(26/153)的孕妇患有合并症,其中3.3%(5/153)感染了艾滋病毒(p<0.000002)。作者强调识别HTLV 1/2感染孕妇对于疾病控制和预防策略的重要性。

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