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脂滴:一个拥有新“外衣”的经典细胞器。

Lipid droplets: a classic organelle with new outfits.

作者信息

Fujimoto Toyoshi, Ohsaki Yuki, Cheng Jinglei, Suzuki Michitaka, Shinohara Yuki

机构信息

Department of Anatomy and Molecular Cell Biology, Graduate School of Medicine, Nagoya University, 65 Tsurumai, Showa, Nagoya, 466-8550, Japan.

出版信息

Histochem Cell Biol. 2008 Aug;130(2):263-79. doi: 10.1007/s00418-008-0449-0. Epub 2008 Jun 11.

Abstract

Lipid droplets are depots of neutral lipids that exist virtually in any kind of cell. Recent studies have revealed that the lipid droplet is not a mere lipid blob, but a major contributor not only to lipid homeostasis but also to diverse cellular functions. Because of the unique structure as well as the functional importance in relation to obesity, steatosis, and other prevailing diseases, the lipid droplet is now reborn as a brand new organelle, attracting interests from researchers of many disciplines.

摘要

脂滴是几乎存在于任何类型细胞中的中性脂质储存库。最近的研究表明,脂滴并非仅仅是一团脂质,而是不仅对脂质稳态而且对多种细胞功能都有重要贡献的主要成分。由于其独特的结构以及在肥胖、脂肪变性和其他常见疾病方面的功能重要性,脂滴如今作为一种全新的细胞器获得重生,吸引了众多学科研究人员的关注。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f23c/2491702/85ff89705419/418_2008_449_Fig1_HTML.jpg

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