巴比妥酸盐安乐死溶液在非人灵长类动物中引起的组织假象。
Barbiturate euthanasia solution-induced tissue artifact in nonhuman primates.
作者信息
Grieves J L, Dick E J, Schlabritz-Loutsevich N E, Butler S D, Leland M M, Price S E, Schmidt C R, Nathanielsz P W, Hubbard G B
机构信息
Veterinary Resources, Southwest National Primate Research Center, Southwest Foundation for Biomedical Research, San Antonio, TX 76227-5301, USA.
出版信息
J Med Primatol. 2008 Jun;37(3):154-61. doi: 10.1111/j.1600-0684.2007.00271.x.
BACKGROUND
Barbiturate euthanasia solutions are a humane and approved means of euthanasia. Overdosing causes significant tissue damage in a variety of laboratory animals.
METHODS
One hundred seventeen non-human primates (NHP) representing 7 species including 12 fetuses euthanized for humane and research reasons by various vascular routes with Euthasol, Sodium Pentobarbital, Fatal Plus, Beuthanasia D, or Euthanasia 5 were evaluated for euthanasia-induced tissue damage. Lungs and livers were histologically graded for hemolysis, vascular damage, edema, and necrosis. Severity of tissue damage was analyzed for differences on the basis of agent, age, sex, dose, and injection route.
RESULTS
Severity of tissue damage was directly related to dose and the intracardiac injection route, but did not differ by species, sex, and agent used.
CONCLUSIONS
When the recommended dose of agent was used, tissue damage was generally reduced, minimal, or undetectable. Barbiturate-induced artifacts in NHPs are essentially the same as in other laboratory species.
背景
巴比妥类安乐死溶液是一种人道且被认可的安乐死方式。过量使用会在多种实验动物身上造成显著的组织损伤。
方法
对117只非人灵长类动物（NHP）进行评估，这些动物代表7个物种，包括12只因人道和研究原因通过不同血管途径使用安乐死灵、戊巴比妥钠、致死加、安乐死D或安乐死5进行安乐死的胎儿，评估安乐死导致的组织损伤情况。对肺和肝脏进行组织学分级，评估溶血、血管损伤、水肿和坏死情况。根据药剂、年龄、性别、剂量和注射途径分析组织损伤的严重程度差异。
结果
组织损伤的严重程度与剂量和心内注射途径直接相关，但在物种、性别和使用的药剂方面没有差异。
结论
当使用推荐剂量的药剂时，组织损伤通常会减轻、最小化或无法检测到。巴比妥类药物在非人灵长类动物中引起的假象与其他实验物种基本相同。
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