Evans A T, Broadstone R, Stapleton J, Hooks T M, Johnston S M, McNeil J R
Veterinary Medical Center, Michigan State University, East Lansing 48824.
J Am Vet Med Assoc. 1993 Sep 1;203(5):664-6.
Pentobarbital alone, pentobarbital plus 1% lidocaine solution, pentobarbital plus 2% lidocaine solution, and pentobarbital plus 3% lidocaine solution were each used to euthanatize 6 dogs. For each dog, time between the beginning of injection of the euthanasia solution and each of the following events was recorded: collapse, onset of apnea, flat-line electrocardiogram, flat-line electroencephalogram, loss of palpable heartbeat, and loss of palpable pulse. Any signs of pain or discomfort were also recorded. There were no significant differences among groups except for time to flat-line electrocardiogram. Dogs euthanatized with pentobarbital alone had significantly longer times than did dogs euthanatized with pentobarbital in combination with any of the lidocaine concentrations. We concluded that pentobarbital in combination with lidocaine was a reasonable alternative to pentobarbital alone when euthanatizing dogs.
分别使用戊巴比妥、戊巴比妥加1%利多卡因溶液、戊巴比妥加2%利多卡因溶液和戊巴比妥加3%利多卡因溶液对6只犬实施安乐死。对于每只犬，记录从开始注射安乐死溶液到出现以下各事件的时间：虚脱、呼吸暂停开始、心电图呈直线、脑电图呈直线、可触及心跳消失以及可触及脉搏消失。还记录了任何疼痛或不适的迹象。除心电图呈直线的时间外，各组之间无显著差异。单独使用戊巴比妥实施安乐死的犬比使用戊巴比妥与任何浓度利多卡因联合实施安乐死的犬所需时间显著更长。我们得出结论，在对犬实施安乐死时，戊巴比妥与利多卡因联合使用是单独使用戊巴比妥的合理替代方法。
