Guyon Alice, Massa Fabienne, Rovère Carole, Nahon Jean-Louis
Institut de Pharmacologie Moléculaire et Cellulaire, UNSA, CNRS, Sophia Antipolis, 660, route des Lucioles, 06560, Valbonne, France.
J Neuroimmunol. 2008 Jul 31;198(1-2):46-55. doi: 10.1016/j.jneuroim.2008.04.009. Epub 2008 Jun 11.
Following inflammation or infection, cytokines are released in the blood. Besides their effect on the immune system, cytokines can also act in the brain to modulate our behaviors, inducing for example anorexia when produced in large amount. This review focuses on our current knowledge on how cytokines can influence the brain and the behaviors through several possible pathways: modulating peripheral neurons which project to the brain through the vagus nerve, modulating the levels of hormones such as leptin which can act to the brain through the humoral pathway and possibly acting directly in the brain, through the local production of cytokines and chemokines such as SDF-1alpha/CXCL12.
在炎症或感染后，细胞因子会释放到血液中。除了对免疫系统有影响外，细胞因子还可在大脑中发挥作用来调节我们的行为，例如大量产生时会诱发厌食症。本综述聚焦于我们目前所了解的细胞因子如何通过几种可能的途径影响大脑和行为：调节通过迷走神经投射到大脑的外周神经元，调节诸如瘦素等可通过体液途径作用于大脑的激素水平，以及可能通过局部产生细胞因子和趋化因子（如SDF-1alpha/CXCL12）直接在大脑中发挥作用。
