Niu Xueting, Ding Yuexia, Chen Shengwei, Gooneratne Ravi, Ju Xianghong
Department of Veterinary Medicine, Guangdong Ocean University, Zhanjiang 524088, China.
Marine Medical Research and Development Centre, Shenzhen Institute of Guangdong Ocean University, Shenzhen 518018, China.
Animals (Basel). 2022 Apr 2;12(7):909. doi: 10.3390/ani12070909.
Immune stress markedly affects the immune function and growth performance of livestock, including poultry, resulting in financial loss to farmers. It can lead to decreased feed intake, reduced growth, and intestinal disorders. Studies have shown that pathogen-induced immune stress is mostly related to TLR4-related inflammatory signal pathway activation, excessive inflammatory cytokine release, oxidative stress, hormonal disorders, cell apoptosis, and intestinal microbial disorders. This paper reviews the occurrence of immune stress in livestock, its impact on immune function and growth performance, and strategies for immune stress prevention.
免疫应激显著影响包括家禽在内的家畜的免疫功能和生长性能，给养殖户造成经济损失。它会导致采食量下降、生长减缓以及肠道紊乱。研究表明，病原体诱导的免疫应激主要与TLR4相关炎症信号通路激活、炎性细胞因子过度释放、氧化应激、激素紊乱、细胞凋亡以及肠道微生物紊乱有关。本文综述了家畜免疫应激的发生情况、其对免疫功能和生长性能的影响以及免疫应激预防策略。
