整合素对免疫突触处的微簇动力学起到制动作用。

Integrins put the brakes on microcluster dynamics at the immunological synapse.

作者信息

Burkhardt Janis K

机构信息

Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

出版信息

Immunity. 2008 Jun;28(6):732-4. doi: 10.1016/j.immuni.2008.05.002.

DOI:10.1016/j.immuni.2008.05.002

PMID:18549795

Abstract

Integrin engagement costimulates T cell receptor signaling, but the underlying mechanisms are poorly understood. In this issue of Immunity, Nguyen et al. (2008) show that engagement of VLA-4 promotes sustained signaling by altering the dynamics of actin filaments and signaling molecules at the immunological synapse.

摘要

整合素的结合共刺激T细胞受体信号传导，但其潜在机制尚不清楚。在本期《免疫》杂志中，Nguyen等人（2008年）表明，VLA-4的结合通过改变免疫突触处肌动蛋白丝和信号分子的动力学来促进持续信号传导。