Maiese Kenneth, Chong Zhao Zhong, Shang Yan Chen, Hou Jinling
Wayne State University School of Medicine, Department of Neurology, 8C-1 UHC, 4201 Street, Antoine, Detroit, MI 48201, USA.
Expert Opin Ther Targets. 2008 Jul;12(7):905-16. doi: 10.1517/14728222.12.7.905.
Disease entities such as diabetes, neurodegeneration and cardiovascular disorders affect a significant portion of the world's population.
Given that cellular survival and longevity in multiple disorders are tied to oxidative stress, apoptotic cell injury and immune system deregulation, the development of robust therapeutic strategies rests heavily upon the ability to balance each of these parameters.
Here we discuss two exciting signaling pathways, namely Wnt and mammalian forkhead transcription factors predominantly of the O class superfamily, which can share integrated cytoprotective pathways during oxidative stress but may also adversely influence cellular survival and promote cancer cell proliferation.
Future investigations must elucidate the cellular determinants that govern the ability of Wnt and forkhead proteins to promote cellular longevity and possible disease remission but also allow for detrimental biological consequences and clinical compromise.
糖尿病、神经退行性疾病和心血管疾病等疾病实体影响着世界上很大一部分人口。
鉴于多种疾病中的细胞存活和寿命与氧化应激、凋亡性细胞损伤和免疫系统失调相关，强大治疗策略的开发在很大程度上取决于平衡这些参数的能力。
在此我们讨论两条令人兴奋的信号通路，即Wnt和主要属于O类超家族的哺乳动物叉头转录因子，它们在氧化应激期间可共享整合的细胞保护通路，但也可能对细胞存活产生不利影响并促进癌细胞增殖。
未来的研究必须阐明决定Wnt和叉头蛋白促进细胞长寿及可能的疾病缓解能力的细胞决定因素，同时也要考虑到有害的生物学后果和临床折衷情况。
