Yang Yu Rong, Craig Philip S, Vuitton Dominique A, Williams Gail M, Sun Tao, Liu Tian Xi, Boufana Belgees, Giraudoux Patrick, Teng Jing, Li Yanbin, Huang Ling, Zhang Wei, Jones Malcolm K, McManus Donald P
Ningxia Medical College, Yinchuan, Ningxia Hui Autonomous Region, PR China.
Trop Med Int Health. 2008 Aug;13(8):1086-94. doi: 10.1111/j.1365-3156.2008.02101.x. Epub 2008 Jun 28.
To assess the usefulness of serology as an indicator of Echinococcus transmission for developing preventive measures against echinococcosis in rural communities.
Cross-sectional survey in 2002 among 861 children aged 7 to 18 years in Xiji County, Ningxia, China. Before ultrasound abdominal examination, a questionnaire was used to identify socioeconomic, sanitary and hygiene risk factors for echinococcal infection; filter paper blood samples were collected from each child for specific antibody detection using EmP (Echinococcus multilocularis) and EgB (Echinococcus granulosus) antigens.
Transmission of both E. multilocularis and E. granulosus occur in this area. Serological prevalence was far higher than disease prevalence in this age range. We found no gender-related differences of seroprevalence among the children, suggesting an equal chance of exposure to echinococcal egg-contaminated environments. The seroprevalence distribution was associated with changes in the ecology of wild hosts for E. multilocularis contamination, and with changes in socio-geographic features of the communities for E. granulosus contamination.
Serological data obtained for children in mass surveys of echinococcosis appear to be a comprehensive and useful tool to monitor changes of transmission dynamics in humans and provide 'warning signals' to decision makers for the instigation of specific control measures against the disease.
评估血清学作为泡型棘球蚴传播指标对于制定农村社区棘球蚴病预防措施的有用性。
2002年在中国宁夏西吉县对861名7至18岁儿童进行横断面调查。在腹部超声检查前，使用问卷确定棘球蚴感染的社会经济、卫生和卫生风险因素；从每个儿童采集滤纸血样，使用多房棘球绦虫（EmP）和细粒棘球绦虫（EgB）抗原进行特异性抗体检测。
该地区同时存在多房棘球绦虫和细粒棘球绦虫的传播。在这个年龄范围内，血清学患病率远高于疾病患病率。我们发现儿童血清阳性率无性别差异，这表明接触棘球绦虫卵污染环境的机会均等。血清阳性率分布与多房棘球绦虫污染的野生宿主生态变化以及细粒棘球绦虫污染的社区社会地理特征变化有关。
在棘球蚴病大规模调查中获得的儿童血清学数据似乎是监测人类传播动态变化的一种全面且有用的工具，并为决策者提供“预警信号”，以便针对该疾病采取具体控制措施。
