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[病态肥胖症行胃大部切除术后的韦尼克脑病]

[Wernicke encephalopathy after subtotal gastrectomy for morbid obesity].

作者信息

Gabaudan C, La-Folie T, Sagui E, Soulier B, Dion A-M, Richez P, Brosset C

机构信息

Service d'imagerie médicale, hôpital Laveran, boulevard Laveran, 13013 Marseille, France.

出版信息

Rev Neurol (Paris). 2008 May;164(5):463-7. doi: 10.1016/j.neurol.2008.01.006. Epub 2008 Mar 26.

Abstract

Wernicke's encephalopathy (WE) is one of the potential complications of obesity surgery. It is an acute neuropsychiatric syndrome resulting from thiamine deficiency often associated with repeated vomiting. The classic triad is frequently reported in these patients (optic neuropathy, ataxia and confusion), associated with uncommon features. Cerebral impairment affects the dorsal medial nucleus of the thalamus and the periaqueductal grey area, appearing on MRI, as hyperintense signals on T2, Flair and Diffusion weighted imaging. Early diagnosis and parenteral thiamine are required to decrease morbidity and mortality. We report a case of WE and Korsakoff's syndrome in a young obese patient after subtotal gastrectomy, who still has substantial sequelae. The contribution of MRI with diffusion-weighted imaging is illustrated. The interest of nutritional supervision in the first weeks and preventive thiamine supplementation in case of repeated vomiting are of particular importance in these risky situations.

摘要

韦尼克脑病(WE)是肥胖手术的潜在并发症之一。它是一种急性神经精神综合征,由硫胺素缺乏引起,常与反复呕吐有关。这些患者常出现经典三联征(视神经病变、共济失调和意识模糊),并伴有一些不常见的特征。脑损伤影响丘脑背内侧核和导水管周围灰质区域,在MRI上表现为T2、Flair和弥散加权成像上的高信号。早期诊断和胃肠外补充硫胺素对于降低发病率和死亡率至关重要。我们报告了一例年轻肥胖患者在胃大部切除术后发生韦尼克脑病和科萨科夫综合征的病例,该患者仍有严重后遗症。阐述了弥散加权成像在MRI中的作用。在这些高危情况下,术后最初几周的营养监测以及反复呕吐时预防性补充硫胺素尤为重要。

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