胰腺癌生物学
Biology of pancreatic cancer.
作者信息
Poston G J, Gillespie J, Guillou P J
机构信息
Academic Surgical Unit, St Mary's Hospital Medical School, London.
出版信息
Gut. 1991 Jul;32(7):800-12. doi: 10.1136/gut.32.7.800.
Abstract
Pancreatic cancer is the fifth leading cause of death from malignant disease in Western society. Apart from the fortunate few patients who present with a resectable small pancreatic adenocarcinoma, conventional treatment offers no hope of cure and has little palliative value. Over the past two decades major steps have been made in our understanding of the biology of pancreatic growth and neoplasia. This review sets out to explore these advances, firstly in the regulation of normal pancreatic growth, and secondly the mechanism which may be involved in malignant change of the exocrine pancreas. From an understanding of this new biology, new treatment strategies may be possible for patients with pancreatic cancer.
摘要
在西方社会，胰腺癌是恶性疾病导致死亡的第五大主要原因。除了少数幸运的可切除小胰腺癌患者外，传统治疗无法治愈，且几乎没有姑息治疗价值。在过去二十年里，我们对胰腺生长和肿瘤形成生物学的理解取得了重大进展。本综述旨在探讨这些进展，首先是正常胰腺生长的调节，其次是外分泌胰腺恶性变化可能涉及的机制。通过了解这种新生物学，有可能为胰腺癌患者制定新的治疗策略。
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