Stedman K E, Moore G E, Morgan R T
Arch Surg. 1980 Mar;115(3):244-8. doi: 10.1001/archsurg.1980.01380030004002.
One hundred three diverse benign and malignant human tissues have been assayed for estrogen receptor proteins. Receptors were detected in many endocrine and nonendocrine tumors. Tissues with estrogen receptor activity included four of five male breast carcinomas, 11 of 14 malignant melanomas, four of eight colon carcinomas, five of seven renal carcinomas, and various sarcomas and benign and normal tissues. Some tumors also had progesterone, androgen, and/or glucocorticoid receptors. These results suggest the use of hormones and hormone antagonists for therapy of a broad range of human cancer. Clinicians of diverse expertise should be aware of, and responsive to, potential endocrinological involvement in many dissimilar disease states.
已对103种不同的人类良性和恶性组织进行了雌激素受体蛋白检测。在许多内分泌和非内分泌肿瘤中都检测到了受体。具有雌激素受体活性的组织包括五例男性乳腺癌中的四例、十四例恶性黑色素瘤中的十一例、八例结肠癌中的四例、七例肾癌中的五例，以及各种肉瘤、良性和正常组织。一些肿瘤还具有孕激素、雄激素和/或糖皮质激素受体。这些结果表明，激素和激素拮抗剂可用于治疗多种人类癌症。不同专业领域的临床医生应意识到并应对许多不同疾病状态中潜在的内分泌参与情况。
