一种来自也门文殊兰的新型酪氨酸酶抑制剂，有望用于治疗色素沉着。
A new tyrosinase inhibitor from Crinum yemense as potential treatment for hyperpigmentation.
作者信息
Abdel-Halim O B, Marzouk A M, Mothana R, Awadh N
机构信息
Department of Pharmacognosy, Faculty of Pharmacy, University of Mansoura, Mansoura, Egypt.
出版信息
Pharmazie. 2008 May;63(5):405-7.
A new pyran derivative, 6-hydroxy-2H-pyran-3-carbaldehyde, has been isolated from the methanolic extract of Crinum yemense along with the known alkaloid haemanthamine, benzoic acid and 1,1'-bis(1,1'-carboxyethyl) ether which is isolated from a natural source for the first time. Structure elucidation of these compounds based on spectroscopicevidences. The pyran derivative was found to be a tyrosinase inhibitor more potent than kojic acid.
从也门文殊兰的甲醇提取物中分离出一种新的吡喃衍生物6-羟基-2H-吡喃-3-甲醛，同时还分离出了已知生物碱海芒果碱、苯甲酸和1,1'-双(1,1'-羧乙基)醚，后者是首次从天然来源分离得到。基于光谱证据对这些化合物进行结构解析。发现该吡喃衍生物是一种比曲酸更有效的酪氨酸酶抑制剂。
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