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人参皂苷生物合成的研究进展。

Progress in understanding of ginsenoside biosynthesis.

作者信息

Liang Y, Zhao S

机构信息

College of Biological and Agricultural Engineering, Jilin University, Changchun, China.

出版信息

Plant Biol (Stuttg). 2008 Jul;10(4):415-21. doi: 10.1111/j.1438-8677.2008.00064.x.

DOI:10.1111/j.1438-8677.2008.00064.x
PMID:18557901
Abstract

Ginseng is an economically important medicinal plant. The major bioactive ingredients of ginseng are ginsenosides, which are triterpene saponins. Because of difficulties in ginseng cultivation and the low productivity of ginseng cell and tissue culture, it has become important to improve ginsenoside levels by using metabolic engineering based on the biosynthetic pathway of ginsenosides. During the last decade, substantial advances have been made in biosynthesis of ginsenosides. This review is concerned with recent developments in our understanding of the biosynthesis of ginsenosides.

摘要

人参是一种具有重要经济价值的药用植物。人参的主要生物活性成分是人参皂苷,它们属于三萜皂苷。由于人参栽培困难以及人参细胞和组织培养的低生产率,基于人参皂苷生物合成途径利用代谢工程提高人参皂苷水平已变得很重要。在过去十年中,人参皂苷的生物合成取得了重大进展。这篇综述关注我们对人参皂苷生物合成理解的最新进展。

相似文献

1
Progress in understanding of ginsenoside biosynthesis.人参皂苷生物合成的研究进展。
Plant Biol (Stuttg). 2008 Jul;10(4):415-21. doi: 10.1111/j.1438-8677.2008.00064.x.
2
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High production of ginsenosides by transformed root cultures of Panax ginseng: effect of basal medium and Agrobacterium rhizogenes strains.人参转化根培养物中人参皂苷的高产:基本培养基和发根农杆菌菌株的影响。
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5
[Comparative studies on the amount of ginsenosides between the crown galls and Chinese medicinal materials of Panax quinquefolium].西洋参冠瘿与中药材中人参皂苷含量的比较研究
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Improved production of ginsenosides in suspension cultures of ginseng by medium replenishment strategy.通过培养基补充策略提高人参悬浮培养中人参皂苷的产量。
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Biosynthesis and biotechnological production of ginsenosides.人参皂苷的生物合成与生物技术生产。
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8
Transcriptomic profiling reveals MEP pathway contributing to ginsenoside biosynthesis in Panax ginseng.转录组分析揭示了 MEP 途径在人参中参与人参皂苷生物合成的作用。
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Cytochrome P450 CYP716A53v2 catalyzes the formation of protopanaxatriol from protopanaxadiol during ginsenoside biosynthesis in Panax ginseng.细胞色素 P450 CYP716A53v2 在人参中催化人参皂苷生物合成过程中从原人参二醇形成原人参三醇。
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Adv Biochem Eng Biotechnol. 2009;113:151-76. doi: 10.1007/10_2008_31.

引用本文的文献

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A Novel Biosynthetic Strategy for Ginsenoside Ro: Construction of a Metabolically Engineered Strain Using a Newly Identified UGAT Gene from as the Key Enzyme Gene and Optimization of Fermentation Conditions.一种新型的人参皂苷 Ro 生物合成策略:利用从 中鉴定的新型 UGAT 基因作为关键酶基因构建代谢工程菌,并优化发酵条件。
Int J Mol Sci. 2024 Oct 21;25(20):11331. doi: 10.3390/ijms252011331.
2
Sustainable production of natural products using synthetic biology: Ginsenosides.利用合成生物学可持续生产天然产物:人参皂苷。
J Ginseng Res. 2024 Mar;48(2):140-148. doi: 10.1016/j.jgr.2023.12.006. Epub 2024 Jan 3.
3
Rare ginsenosides: A unique perspective of ginseng research.
稀有皂苷:人参研究的独特视角。
J Adv Res. 2024 Dec;66:303-328. doi: 10.1016/j.jare.2024.01.003. Epub 2024 Jan 7.
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Regulation of transcriptome networks that mediate ginsenoside biosynthesis by essential ecological factors.调控转录组网络,介导人参皂苷生物合成的基本生态因素。
PLoS One. 2023 Aug 17;18(8):e0290163. doi: 10.1371/journal.pone.0290163. eCollection 2023.
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The Transcription Factor Gene Involved in the Regulation of Ginsenoside Biosynthesis in .人参中参与人参皂苷生物合成调节的转录因子基因。
Int J Mol Sci. 2023 Jul 26;24(15):11946. doi: 10.3390/ijms241511946.
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Advances in the biosynthesis and metabolic engineering of rare ginsenosides.稀有 Ginsenosides 的生物合成和代谢工程的进展。
Appl Microbiol Biotechnol. 2023 Jun;107(11):3391-3404. doi: 10.1007/s00253-023-12549-6. Epub 2023 May 1.
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Plants (Basel). 2023 Mar 1;12(5):1091. doi: 10.3390/plants12051091.
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