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利用合成生物学可持续生产天然产物：人参皂苷。

Sustainable production of natural products using synthetic biology: Ginsenosides.

作者信息

Son So-Hee, Kang Jin, Shin YuJin, Lee ChaeYoung, Sung Bong Hyun, Lee Ju Young, Lee Wonsik

机构信息

Research Center for Bio-Based Chemistry, Korea Research Institute of Chemical Technology (KRICT), Ulsan, Republic of Korea.

Synthetic Biology Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea.

出版信息

J Ginseng Res. 2024 Mar;48(2):140-148. doi: 10.1016/j.jgr.2023.12.006. Epub 2024 Jan 3.

DOI:10.1016/j.jgr.2023.12.006
PMID:38465212
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10920010/
Abstract

Synthetic biology approaches offer potential for large-scale and sustainable production of natural products with bioactive potency, including ginsenosides, providing a means to produce novel compounds with enhanced therapeutic properties. Ginseng, known for its non-toxic and potent qualities in traditional medicine, has been used for various medical needs. Ginseng has shown promise for its antioxidant and neuroprotective properties, and it has been used as a potential agent to boost immunity against various infections when used together with other drugs and vaccines. Given the increasing demand for ginsenosides and the challenges associated with traditional extraction methods, synthetic biology holds promise in the development of therapeutics. In this review, we discuss recent developments in microorganism producer engineering and ginsenoside production in microorganisms using synthetic biology approaches.

摘要

合成生物学方法为大规模可持续生产具有生物活性的天然产物（包括人参皂苷）提供了潜力，这为生产具有增强治疗特性的新型化合物提供了一种手段。人参在传统医学中以其无毒且功效显著而闻名，已被用于满足各种医疗需求。人参已显示出其抗氧化和神经保护特性的潜力，并且当与其他药物和疫苗一起使用时，它已被用作增强针对各种感染的免疫力的潜在药物。鉴于对人参皂苷的需求不断增加以及传统提取方法面临的挑战，合成生物学在治疗药物开发方面具有前景。在本综述中，我们讨论了利用合成生物学方法在微生物生产者工程和微生物中人参皂苷生产方面的最新进展。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/427d/10920010/1fbaad8c2554/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/427d/10920010/f330b56f906d/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/427d/10920010/ff1e64ed72d5/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/427d/10920010/37dcbec45f35/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/427d/10920010/254ed3fd467a/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/427d/10920010/1fbaad8c2554/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/427d/10920010/f330b56f906d/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/427d/10920010/ff1e64ed72d5/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/427d/10920010/37dcbec45f35/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/427d/10920010/254ed3fd467a/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/427d/10920010/1fbaad8c2554/gr4.jpg

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本文引用的文献

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Front Pharmacol. 2023 Apr 28;14:1177819. doi: 10.3389/fphar.2023.1177819. eCollection 2023.
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SynBioTools: a one-stop facility for searching and selecting synthetic biology tools.SynBioTools：一站式搜索和选择合成生物学工具的平台。
BMC Bioinformatics. 2023 Apr 17;24(1):152. doi: 10.1186/s12859-023-05281-5.
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High-yield production of protopanaxadiol from sugarcane molasses by metabolically engineered Saccharomyces cerevisiae.
MicroRNA介导的人参皂苷生物合成调控及其生物技术意义。
Sci Prog. 2025 Apr-Jun;108(2):368504251332109. doi: 10.1177/00368504251332109. Epub 2025 Mar 31.
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Anti-Colorectal Cancer Activity of and Its Active Components, Ginsenosides: A Review.人参及其活性成分人参皂苷的抗结直肠癌活性：综述
Int J Mol Sci. 2025 Mar 13;26(6):2593. doi: 10.3390/ijms26062593.
通过代谢工程化酿酒酵母从甘蔗废糖蜜中高产制备原人参二醇。
Microb Cell Fact. 2022 Nov 5;21(1):230. doi: 10.1186/s12934-022-01949-4.
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Anti-cancer effect and potential microRNAs targets of ginsenosides against breast cancer.人参皂苷对乳腺癌的抗癌作用及潜在的微小RNA靶点
Front Pharmacol. 2022 Oct 5;13:1033017. doi: 10.3389/fphar.2022.1033017. eCollection 2022.
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Novel Split Intein-Mediated Enzymatic Channeling Accelerates the Multimeric Bioconversion Pathway of Ginsenoside.新型分裂内含肽介导的酶促通道加速了人参皂苷的多聚体生物转化途径。
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