男性乳腺癌：情况正在改变吗？
Male breast cancer: is the scenario changing.
作者信息
Contractor Kaiyumars B, Kaur Kanchan, Rodrigues Gabriel S, Kulkarni Dhananjay M, Singhal Hemant
机构信息
Department of Surgery, Oncology, Reproductive Medicine and Anaesthetics, Imperial College, London, UK.
出版信息
World J Surg Oncol. 2008 Jun 16;6:58. doi: 10.1186/1477-7819-6-58.
BACKGROUND
The overall incidence of male breast cancer is around 1% of all breast cancers and is on the rise. In this review we aim to present various aspects of male breast cancer with particular emphasis on incidence, risk factors, patho-physiology, treatment, prognostic factors, and outcome.
METHODS
Information on all aspects of male breast cancer was gathered from available relevant literature on male breast cancer from the MEDLINE database over the past 32 years from 1975 to 2007. Various reported studies were scrutinized for emerging evidence. Incidence data were also obtained from the IARC, Cancer Mondial database.
CONCLUSION
There is a scenario of rising incidence, particularly in urban US, Canada and UK. Even though more data on risk factors is emerging about this disease, more multi-institutional efforts to pool data with large randomized trials to show treatment and survival benefits are needed to support the existing vast emerging knowledge about the disease.
背景
男性乳腺癌的总体发病率约占所有乳腺癌的1%，且呈上升趋势。在本综述中，我们旨在阐述男性乳腺癌的各个方面，特别着重于发病率、危险因素、病理生理学、治疗、预后因素及转归。
方法
关于男性乳腺癌各方面的信息，是从1975年至2007年过去32年间MEDLINE数据库中有关男性乳腺癌的现有相关文献收集而来。对各项已报道的研究进行仔细审查以获取新出现的证据。发病率数据也从国际癌症研究机构（IARC）的全球癌症数据库中获取。
结论
存在发病率上升的情况，尤其是在美国、加拿大和英国的城市地区。尽管关于这种疾病的危险因素有了更多数据，但仍需要更多多机构合作，通过大型随机试验汇总数据以显示治疗和生存获益，来支持现有的大量新出现的关于该疾病的知识。
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