工程企业男性工人手臂振动与雷诺现象发病关系的队列研究。
Incidence of Raynaud's phenomenon in relation to hand-arm vibration exposure among male workers at an engineering plant a cohort study.
机构信息
Department of Occupational and Environmental Medicine, University of Gothenburg, Sweden.
出版信息
J Occup Med Toxicol. 2008 Jun 16;3:13. doi: 10.1186/1745-6673-3-13.
BACKGROUND
The objective of this study was to assess the incidence of Raynaud's phenomenon in relation to hand-arm vibration exposure in a cohort consisting of male office and manual workers.
METHODS
The baseline population consisted of 94 office and 147 manual workers at an engineering plant. Raynaud's phenomenon (RP) was assessed at baseline and at follow up (at 5, 10 and 15 years). A retrospective and a prospective cohort analysis of data were done. Hand-arm vibration exposure dose was defined as the product of exposure duration and the weighted hand-arm vibration exposure value according to ISO 5349-1.
RESULTS
The retrospective/prospective incidence of Raynaud's phenomenon was 16/14 per 1000 exposure years among exposed and 2.4/5.0 per 1000 years among the not exposed. The retrospective dose response curve based on 4 dose classes showed that class 2, 3 and 4 had similar response and showed higher incidence than the not-exposed. The dose with RP response to hand-arm vibration corresponded to a 10 year A(8) value between 0.4-1.0 m/s2.
CONCLUSION
The results indicate that the EU directive on an action value for hand-arm vibration of 2.5 m/s2 is not too low. Rather, it suggests that employers should take on actions even at exposure values of 1 m/s2A(8).
背景
本研究旨在评估与手部手臂振动暴露相关的雷诺现象的发生率，研究对象为男性办公室和体力劳动者队列。
方法
基础人群由工程工厂的 94 名办公室工作人员和 147 名体力劳动者组成。在基线和随访（5、10 和 15 年）时评估雷诺现象（RP）。对数据进行回顾性和前瞻性队列分析。手部手臂振动暴露剂量定义为暴露持续时间与 ISO 5349-1 规定的加权手部手臂振动暴露值的乘积。
结果
暴露组的雷诺现象回顾性/前瞻性发生率为每 1000 暴露年 16/14 例，未暴露组为每 1000 年 2.4/5.0 例。基于 4 个剂量组的回顾性剂量反应曲线表明，第 2、3 和 4 组的反应相似，且发病率高于未暴露组。手部手臂振动引起 RP 的剂量对应于 10 年 A(8)值在 0.4-1.0 m/s2 之间。
结论
结果表明，欧盟关于手部手臂振动的行动值为 2.5 m/s2 的指令并不太低。相反，它表明雇主即使在 1 m/s2A(8) 的暴露值下也应采取行动。
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