Caygill C P, Leach S A, Fernandez F, Duncan S, Hill M J, Massey R, Hall R
Public Health Laboratory Service, Communicable Disease Surveillance Centre, London, UK.
IARC Sci Publ. 1991(105):137-8.
Evidence is presented that N-nitroso compounds occur in bile from patients who have undergone surgery for gallstones or had gastrectomy and from unoperated persons. It is unlikely, therefore, that local formation of nitrosamines can account for the excess risk for gallbladder cancer in the first two groups. Gastric formation remains the likeliest hypothesis.
有证据表明，在接受过胆结石手术或胃切除术的患者以及未接受手术的人的胆汁中存在N-亚硝基化合物。因此，亚硝胺的局部形成不太可能解释前两组中胆囊癌风险增加的原因。胃内形成仍然是最有可能的假设。
