Shi K X, Mao D J, Cheng W F, Ji Y S, Xu L Z
Department of Public Health, Shanghai Second Medical University, China.
IARC Sci Publ. 1991(105):143-5.
Although gastric cancer is the most common cause of mortality from cancer, its etiology is not yet clear. To elucidate the role of N-nitroso compounds, we investigated 30 cases of gastric cancer by determination of the contents of nitrate and ascorbic acid and by detection of mutagens in urine. Cases were paired 1:1 with patients with dysplasia and normal controls of the same sex and age group. In comparison with normal controls, the gastric cancer group had higher nitrate and lower ascorbic acid levels in urine. Mutagenicity was observed in the urines of 83.3% of the gastric cancer cases and in 16.6% of the dysplasia group, but in none of those from normal controls. When the N-nitroso compound content of gastric juice was determined, the levels in control subjects were significantly lower than those in persons with gastric cancer. These results support the hypothesis that the cause of gastric cancer may be N-nitroso compounds.
尽管胃癌是癌症致死的最常见原因，但其病因尚不清楚。为阐明N-亚硝基化合物的作用，我们通过测定硝酸盐和抗坏血酸含量以及检测尿液中的诱变剂，对30例胃癌患者进行了调查。病例与发育异常患者及相同性别和年龄组的正常对照按1:1配对。与正常对照相比，胃癌组尿液中的硝酸盐含量较高，抗坏血酸水平较低。83.3%的胃癌病例尿液中观察到诱变活性，发育异常组为16.6%，而正常对照组均未观察到。测定胃液中N-亚硝基化合物含量时，对照组水平显著低于胃癌患者。这些结果支持胃癌病因可能是N-亚硝基化合物这一假说。
