Department of Otolaryngology, Taichung Veterans General Hospital, Taichung, Taiwan.
Am J Rhinol Allergy. 2009 Nov-Dec;23(6):582-4. doi: 10.2500/ajra.2009.23.3370.
Olfactory bulb (OB) volume has been shown to be an indicator of olfactory function. However, few studies have been done in Asia to investigate the influence of different disorders on OB volume.
Data from patients with posttraumatic anosmia were collected in our department. Their olfactory thresholds were assessed by the phenyl ethyl alcohol threshold test. They were treated with a course of high-dose steroid, and followed up for at least 3 months without any olfactory improvement. Magnetic resonance imaging was subsequently used to measure patients' OB volumes. Subjects who self-reported their olfactory function was normal were also included in the control group for comparison.
Fifty-four patients with posttraumatic anosmia and 30 subjects who self-reported their olfactory function was normal were enrolled in this study. The mean right OB volume was 45.2 mm3, and the mean left OB volume was 46.3 mm3 in patients with posttraumatic anosmia. The mean right OB volume was 59.7 mm3, and the mean left OB volume was 66.0 mm3 in control subjects. The OB volumes were significantly lower in patients with posttraumatic anosmia.
OB volumes were significantly lower in Taiwanese patients with posttraumatic anosmia.
嗅球（OB）体积已被证明是嗅觉功能的一个指标。然而，亚洲地区很少有研究探讨不同疾病对 OB 体积的影响。
本研究在我院收集了外伤性嗅觉丧失患者的数据。他们的嗅觉阈值通过苯乙醇阈值测试进行评估。他们接受了一个疗程的大剂量类固醇治疗，并且在没有任何嗅觉改善的情况下至少随访 3 个月。随后使用磁共振成像来测量患者的 OB 体积。自我报告嗅觉功能正常的受试者也被纳入对照组进行比较。
本研究共纳入 54 例外伤性嗅觉丧失患者和 30 例自我报告嗅觉功能正常的受试者。外伤性嗅觉丧失患者的右侧 OB 平均体积为 45.2mm³，左侧 OB 平均体积为 46.3mm³。对照组受试者的右侧 OB 平均体积为 59.7mm³，左侧 OB 平均体积为 66.0mm³。外伤性嗅觉丧失患者的 OB 体积明显较小。
台湾地区外伤性嗅觉丧失患者的 OB 体积明显较小。
