一种用于单针孔小动物自适应单光子发射计算机断层显像（SPECT）成像的原型仪器。
A prototype instrument for single pinhole small animal adaptive SPECT imaging.
作者信息
Freed Melanie, Kupinski Matthew A, Furenlid Lars R, Wilson Donald W, Barrett Harrison H
机构信息
U.S. Food and Drug Administration, 10903 New Hampshire Avenue, Building 62, Room 3133, Silver Spring, Maryland 20993-0002, USA.
出版信息
Med Phys. 2008 May;35(5):1912-25. doi: 10.1118/1.2896072.
The authors have designed and constructed a small-animal adaptive SPECT imaging system as a prototype for quantifying the potential benefit of adaptive SPECT imaging over the traditional fixed geometry approach. The optical design of the system is based on filling the detector with the region of interest for each viewing angle, maximizing the sensitivity, and optimizing the resolution in the projection images. Additional feedback rules for determining the optimal geometry of the system can be easily added to the existing control software. Preliminary data have been taken of a phantom with a small, hot, offset lesion in a flat background in both adaptive and fixed geometry modes. Comparison of the predicted system behavior with the actual system behavior is presented, along with recommendations for system improvements.
作者设计并构建了一个小动物自适应单光子发射计算机断层扫描（SPECT）成像系统，作为一个原型，用于量化自适应SPECT成像相对于传统固定几何方法的潜在益处。该系统的光学设计基于针对每个视角用感兴趣区域填充探测器，以最大化灵敏度，并优化投影图像中的分辨率。用于确定系统最佳几何形状的额外反馈规则可以很容易地添加到现有的控制软件中。已经在自适应和固定几何模式下获取了一个在平坦背景中有一个小的、热的、偏移病变的体模的初步数据。给出了预测的系统行为与实际系统行为的比较，以及对系统改进的建议。
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