从甾体烯胺方便地制备A环稠合吡啶。
Convenient preparation of A-ring fused pyridines from steroidal enamides.
作者信息
Barthakur Madan G, Borthakur Moyurima, Boruah Romesh C
机构信息
Medicinal Chemistry Division, North-East Institute of Science and Technology, Jorhat, Assam 785006, India.
出版信息
Steroids. 2008 Oct;73(11):1137-42. doi: 10.1016/j.steroids.2008.04.016. Epub 2008 May 9.
Abstract
A facile strategy for the preparation of A-ring fused pyridosteroids has been accomplished in high yields by the reaction of Vilsmeier reagent (chloromethyleneiminium salt) with steroidal A-ring enamides (2- and 3-ene) under thermal conditions. The structure of 6'-chloro-5alpha-cholest [3,2-b]pyridine was determined by X-ray analysis.
摘要
通过Vilsmeier试剂（氯亚甲基亚铵盐）与甾体A环烯酰胺（2-烯和3-烯）在热条件下反应，以高收率实现了一种制备A环稠合吡啶甾体的简便策略。通过X射线分析确定了6'-氯-5α-胆甾[3,2-b]吡啶的结构。
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