Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, China.
Clinical Hospital of the Chengdu Brain Science Institute, MOE Key Laboratory for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, China.
Brain Struct Funct. 2018 Nov;223(8):3813-3840. doi: 10.1007/s00429-018-1727-9. Epub 2018 Aug 6.
The inability to control or inhibit emotional distractors characterizes a range of psychiatric disorders. Despite the use of a variety of task paradigms to determine the mechanisms underlying the control of emotional interference, a precise characterization of the brain regions and networks that support emotional interference processing remains elusive. Here, we performed coordinate-based and functional connectivity meta-analyses to determine the brain networks underlying emotional interference. Paradigms addressing interference processing in the cognitive or emotional domain were included in the meta-analyses, particularly the Stroop, Flanker, and Simon tasks. Our results revealed a consistent involvement of the bilateral dorsal anterior cingulate cortex, anterior insula, left inferior frontal gyrus, and superior parietal lobule during emotional interference. Follow-up conjunction analyses identified correspondence in these regions between emotional and cognitive interference processing. Finally, the patterns of functional connectivity of these regions were examined using resting-state functional connectivity and meta-analytic connectivity modeling. These regions were strongly connected as a distributed system, primarily mapping onto fronto-parietal control, ventral attention, and dorsal attention networks. Together, the present findings indicate that a domain-general neural system is engaged across multiple types of interference processing and that regulating emotional and cognitive interference depends on interactions between large-scale distributed brain networks.
无法控制或抑制情绪干扰特征是一系列精神疾病。尽管使用了各种任务范式来确定控制情绪干扰的机制，但支持情绪干扰处理的大脑区域和网络的精确特征仍然难以捉摸。在这里，我们进行了基于坐标和功能连接的荟萃分析，以确定情绪干扰的大脑网络。荟萃分析中包括了处理认知或情绪领域干扰的范式，特别是 Stroop、Flanker 和 Simon 任务。我们的结果表明，在情绪干扰过程中双侧背侧前扣带皮层、前岛叶、左侧额下回和顶叶上回始终参与其中。后续的联合分析确定了这些区域在情绪和认知干扰处理之间的对应关系。最后，使用静息态功能连接和荟萃分析连接建模检查了这些区域的功能连接模式。这些区域作为一个分布式系统紧密连接，主要映射到额顶控制、腹侧注意和背侧注意网络。总之，这些发现表明，一个通用的神经系统参与了多种类型的干扰处理，而调节情绪和认知干扰取决于大脑大尺度分布式网络之间的相互作用。
