Hillilä M T, Hämäläinen J, Heikkinen M E, Färkkilä M A
Division of Gastroenterology, Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland.
Aliment Pharmacol Ther. 2008 Sep 1;28(5):648-54. doi: 10.1111/j.1365-2036.2008.03771.x. Epub 2008 Jun 28.
Patients with depression have irritable bowel syndrome (IBS) more often than do nondepressed patients, but the comorbidity of depression and gastrointestinal (GI) symptoms in the general population has received little study.
To study the co-occurrence of depressive and GI symptoms in a general population sample and to assess the rate of health-care utilization particularly for GI reasons among subjects with depressive symptoms.
A questionnaire containing the Finnish version of the Beck Depression Inventory Short Form and questions covering GI symptoms according to Rome II criteria was mailed to 5000 randomly selected adults.
Response rate was 73%. Prevalence of depressive symptoms was 17% (95% CI: 15.7-18.2). Frequent abdominal pain, diarrhoea, constipation, dyspepsia or IBS were present in 54% of those with depressive symptoms and in 29% of nondepressed controls (P < 0.0001). Of those with depressive symptoms, 24% had visited a physician at least once because of abdominal symptoms during the previous year, compared to 13% of controls (P < 0.0001).
Depressive symptoms are prevalent in the general population. They are associated with a high rate of GI symptoms, leading to increased use of health-care services and work absenteeism because of abdominal complaints.
抑郁症患者比非抑郁症患者更常出现肠易激综合征（IBS），但普通人群中抑郁症与胃肠道（GI）症状的共病情况鲜有研究。
研究普通人群样本中抑郁症状与胃肠道症状的共现情况，并评估有抑郁症状的受试者因胃肠道原因的医疗保健利用率。
向5000名随机选取的成年人邮寄一份包含芬兰版贝克抑郁量表简版以及根据罗马II标准涵盖胃肠道症状问题的问卷。
回复率为73%。抑郁症状的患病率为17%（95%可信区间：15.7 - 18.2）。有抑郁症状者中54%存在频繁腹痛、腹泻、便秘、消化不良或肠易激综合征，无抑郁症状的对照组中这一比例为29%（P < 0.0001）。有抑郁症状者中，24%在过去一年中因腹部症状至少看过一次医生，而对照组为13%（P < 0.0001）。
抑郁症状在普通人群中普遍存在。它们与高比例的胃肠道症状相关，导致因腹部不适而增加医疗保健服务的使用和旷工情况。
