Barrett D M, O'Sullivan D C, Malizia A A, Reiman H M, Abell-Aleff P C
Department of Urology, Mayo Clinic, Rochester Minnesota 55905.
J Urol. 1991 Aug;146(2):319-22. doi: 10.1016/s0022-5347(17)37780-7.
Of 26 patients undergoing revision of genitourinary prostheses the surrounding reactive fibrous capsule was biopsied in 25 and the draining lymph nodes also were biopsied in 4. The prostheses included 16 inflatable and 14 flexible penile devices, and 10 artificial urinary sphincters. Tissue was examined by light and transmission electron microscopy. X-ray microanalysis was done on intracellular and extracellular foreign material from each specimen. Silicone was found in 18 of the 25 periprosthetic specimens and in all 4 lymph nodes. Foreign body granulomas were identified in 14 of these 29 specimens. Examination of new and explanted versions of each prosthesis by scanning electron microscopy revealed free particles of silicone or silicates on the surface of most devices. Pitting and microfissuring were seen on a few of the new devices and on nearly all of the used ones. Thus, genitourinary prostheses shed silicone particles that can be found in the fibrous capsule and draining lymph nodes.
在26例接受泌尿生殖假体翻修的患者中，对25例患者周围的反应性纤维囊进行了活检，对4例患者的引流淋巴结也进行了活检。这些假体包括16个可膨胀阴茎假体和14个柔性阴茎假体，以及10个人造尿道括约肌。通过光学显微镜和透射电子显微镜对组织进行检查。对每个标本的细胞内和细胞外异物进行了X射线微分析。在25个假体周围标本中的18个以及所有4个淋巴结中发现了硅酮。在这29个标本中的14个中发现了异物肉芽肿。通过扫描电子显微镜检查每个假体的新的和取出的版本，发现在大多数装置的表面有游离的硅酮或硅酸盐颗粒。在一些新装置和几乎所有用过的装置上都观察到了点蚀和微裂纹。因此，泌尿生殖假体可脱落硅酮颗粒，这些颗粒可在纤维囊和引流淋巴结中发现。
