Hoffmann Barbara, Hertel Sabine, Boes Tanja, Weiland Dorothea, Jöckel Karl-Heinz
Institute for Medical Informatics, Biometry and Epidemiology, University Hospital, University of Duisburg-Essen, Essen, Germany.
J Toxicol Environ Health A. 2008;71(11-12):759-65. doi: 10.1080/15287390801985539.
During the 2003 heat wave an increase in mortality was observed in several European countries. Evidence suggests that the heat wave effect on mortality varies based upon underlying disease. In this study we examined the effects of the 2003 heat wave on all-cause and cause-specific mortality (neoplasms, cardiovascular and respiratory diseases) in a large west German city. Daily weather data for Essen was obtained from the German meteorological service. Death certificates for all deaths in Essen from 2002 to 2003 were coded according to the World Health Organization (WHO) guidelines. Mean numbers of daily deaths during and after the heat wave were compared with the average mortality in summer months (reference period). Poisson generalized additive models, adjusted for weekday and season, were fitted for overall and cause-specific mortality for the entire study period. During the 2003 heat wave (August 6-12), daily mortality increased by 15% (neoplasms), 30% (cardiovascular), and 61% (respiratory), with a decrease in the week after the heat wave of 17% for neoplasms and a sustained rise for respiratory mortality (77%). Regression analysis showed an association between heat and overall mortality in 2003 and greatest associations for respiratory mortality. Even the comparatively short heat wave in Essen in the year 2003 was associated with a rise in overall and cause-specific mortality. Different mechanisms appear to influence cause-specific mortality, with strongest associations for respiratory mortality. Harvesting might play a role in mortality due to neoplasms.
2003年热浪期间,几个欧洲国家的死亡率有所上升。有证据表明,热浪对死亡率的影响因潜在疾病而异。在本研究中,我们调查了2003年热浪对德国西部一个大城市全因死亡率和特定病因死亡率(肿瘤、心血管疾病和呼吸系统疾病)的影响。埃森市的每日天气数据来自德国气象服务部门。根据世界卫生组织(WHO)的指南,对2002年至2003年埃森市所有死亡的死亡证明进行编码。将热浪期间及之后的每日死亡平均数与夏季月份的平均死亡率(参考期)进行比较。针对整个研究期间的总体死亡率和特定病因死亡率,拟合了经工作日和季节调整的泊松广义相加模型。在2003年热浪期间(8月6日至12日),每日死亡率分别上升了15%(肿瘤)、30%(心血管疾病)和61%(呼吸系统疾病),热浪过后一周肿瘤死亡率下降了17%,而呼吸系统疾病死亡率持续上升(77%)。回归分析显示,2003年高温与总体死亡率之间存在关联,与呼吸系统疾病死亡率的关联最为显著。即使是2003年埃森市相对较短的热浪也与总体死亡率和特定病因死亡率的上升有关。不同机制似乎影响特定病因死亡率,其中与呼吸系统疾病死亡率的关联最为强烈。收割可能在肿瘤导致的死亡率中起作用。