Rajendran P, Ekambaram G, Sakthisekaran D
Department of Medical Biochemistry, University of Madras, Chennai 600 113, India.
Nat Prod Res. 2008 May 20;22(8):672-80. doi: 10.1080/14786410701824973.
The present study is an effort to identify a potent chemopreventive agent against cancer, in which oxidative stress plays an important causative role. The modulatory effect of mangiferin on mitochondrial lipid peroxidation (LPO), tricarboxylic acid (TCA) cycle key enzymes and electron transport chain complexes was investigated against lung carcinogenesis induced by benzo(a)pyrene (50 mg kg(-1) b/w orally) in Swiss albino mice. Decreased activities of electron transport chain complexes and TCA cycle key enzymes such as isocitrate dehydrogenase (ICDH), succinate dehydrogenase (SDH), malate dehydrogenase (MDH) and alpha-ketoglutarate dehydrogenase (alpha-KGDH), in lung cancer bearing animals were observed. Pre- and post-treatment with mangiferin (100 mg kg(-1) b/w orally) for 18 weeks, prevented the above biochemical changes, which were inclined towards normal control animal values. This study further confirms the chemopreventive and chemotherapeutic effect of mangiferin and these results are consistent with our hypothesis that mangiferin is a promising chemopreventive agent.
本研究旨在确定一种有效的抗癌化学预防剂，其中氧化应激起着重要的致病作用。研究了芒果苷对瑞士白化小鼠中由苯并(a)芘（50 mg kg(-1) 体重，口服）诱导的肺癌发生过程中线粒体脂质过氧化（LPO）、三羧酸（TCA）循环关键酶和电子传递链复合物的调节作用。观察到荷肺癌动物中电子传递链复合物和TCA循环关键酶如异柠檬酸脱氢酶（ICDH）、琥珀酸脱氢酶（SDH）、苹果酸脱氢酶（MDH）和α-酮戊二酸脱氢酶（α-KGDH）的活性降低。用芒果苷（100 mg kg(-1) 体重，口服）进行18周的预处理和后处理，可防止上述生化变化，使其趋向于正常对照动物的值。本研究进一步证实了芒果苷的化学预防和化疗作用，这些结果与我们的假设一致，即芒果苷是一种有前途的化学预防剂。
