菲律宾龙脑香的次生代谢产物。

Secondary metabolites from Tectona philippinensis.

作者信息

Ragasa Consolacion Y, Lapina Maria Claribel, Lee Jadz Jevz, Mandia Emelina H, Rideout John A

机构信息

Chemistry Department, De La Salle University, 1004 Manila.

出版信息

Nat Prod Res. 2008 Jun 15;22(9):820-4. doi: 10.1080/14786410701640551.

DOI:10.1080/14786410701640551

PMID:18569722

Abstract

The air-dried leaves of Tectona philippinensis, an endemic and endangered Philippine medicinal plant, afforded 5-hydroxy-3,7,4'-trimethoxyflavone (1), 5,4'-dihydroxy-3,7-dimethoxyflavone (2), squalene (3), a mixture of lupeol (4a) and beta-amyrin (4b), chlorophyllide a (5), and hydrocarbons. Antimicrobial tests on 1 and 2 indicated low antifungal activity against the fungi, Candida albicans and Trichophyton mentagrophytes. Compound 1 was also found to have low antibacterial activity against Escherichia coli and Pseudomonas aeruginosa.

摘要

菲律宾龙脑香（Tectona philippinensis）是一种菲律宾特有的濒危药用植物，其风干叶片含有5-羟基-3,7,4'-三甲氧基黄酮（1）、5,4'-二羟基-3,7-二甲氧基黄酮（2）、角鲨烯（3）、羽扇豆醇（4a）和β-香树脂醇（4b）的混合物、焦脱镁叶绿酸a（5）以及碳氢化合物。对1和2进行的抗菌测试表明，它们对白色念珠菌和须癣毛癣菌的抗真菌活性较低。还发现化合物1对大肠杆菌和铜绿假单胞菌的抗菌活性较低。