Ignatenko L L, Mataradze G D, Vaĭntraub M G, Buniatian A F, Rozen V B
Probl Endokrinol (Mosk). 1991 Mar-Apr;37(2):53-5.
A study was made of the endocrine mechanisms of the formation and maintenance of a sex-differentiated level of estrogen receptors (ER) in rat liver cytosol. The administration of testosterone-propionate (TP) at a dose of 3 mg for 3 days was shown to cause a significant decrease in the concentration of ER in the liver of gonadectomized animals to the level in intact male rats. In a week after the discontinuation of TP, a complete restoration of the basal level of receptors was observed. Neonatal and prepubertal administration of TP to gonadectomized male rats at early stages of ontogenesis made no effect on the level of ER in the liver cytosol of these animals at the age of 12-14 weeks. The removal of the adrenal and thyroid glands produced no changes in the level of ER in the liver of rats of both sexes. Hypophysectomy in rats resulted even on the 1st day in a decrease in ER concentration in the liver of male and female animals to the same basal level which later on remained unchanged. Ectopic transplantation of a homologous hypophysis and human STH administration led to a significant rise of the level of ER in hypophysectomized animals. TP inhibited a stimulating effect of STH in rats with the removed hypophysis.
对大鼠肝胞质溶胶中雌激素受体（ER）性别分化水平形成和维持的内分泌机制进行了研究。结果显示，以3毫克丙酸睾酮（TP）的剂量给药3天，可使去性腺动物肝脏中ER的浓度显著降低至完整雄性大鼠的水平。在停用TP一周后，观察到受体基础水平完全恢复。在个体发育早期，对去性腺的雄性大鼠进行新生期和青春期前TP给药，对这些动物12 - 14周龄时肝胞质溶胶中ER的水平没有影响。切除肾上腺和甲状腺对两性大鼠肝脏中ER的水平没有产生变化。大鼠垂体切除术后，即使在第1天，雄性和雌性动物肝脏中ER的浓度也会降低至相同的基础水平，且随后保持不变。同源垂体的异位移植和人促生长激素（STH）的给药导致垂体切除动物中ER水平显著升高。TP抑制了垂体切除大鼠中STH的刺激作用。
