Smirnova O V, Vishniakova T G, Kurabekova R M, Rozen V B
Probl Endokrinol (Mosk). 1986 May-Jun;32(3):65-9.
A study was made of the role of the hypophysis and STH in the regulation of the level of specific estrogen-binding protein (SEBP) and estrogen receptors (ER) in the rat liver, in the expression of the SEPB-determining effect of androgens (A) and the regulating action of estrogens (E) on the SEPB level. The SEPB and ER content was determined by quantitative methods permitting the differential testing of one E-binding protein from another. Hypophysectomy of males caused a decrease in the SEPB and ER levels. STH administration increased the SEPB and ER levels in the liver of the hypophysectomized males but did not influence the level of these proteins in intact animals. Hypophysectomy of intact and ovariectomized females blocked the SEPB-determining action of A even at early time after operation. Estrogens (E) were capable of producing an inhibitory effect on the SEPB level at early time after hypophysectomy of males. The efficacy of E action after hypophysectomy decreased in parallel with a decrease in the ER content in the liver. The administration of STH to hypophysectomized males resulted in an increase in the ER level and a subsequent reduction of SEPB negative reaction to E. It was concluded that hypophysial factors could produce a direct, sensitizing and permissive for sex steroids action on the SEPB level.
对垂体和生长激素（STH）在调节大鼠肝脏中特异性雌激素结合蛋白（SEBP）和雌激素受体（ER）水平、雄激素（A）对SEPB的决定作用以及雌激素（E）对SEPB水平的调节作用的表达方面所起的作用进行了研究。通过定量方法测定SEPB和ER的含量，该方法允许对一种雌激素结合蛋白与另一种进行差异检测。雄性大鼠垂体切除导致SEPB和ER水平降低。给垂体切除的雄性大鼠注射生长激素可提高肝脏中SEPB和ER的水平，但对完整动物中这些蛋白的水平没有影响。完整和去卵巢雌性大鼠垂体切除即使在术后早期也会阻断A对SEPB的决定作用。雄性大鼠垂体切除后早期，雌激素（E）能够对SEPB水平产生抑制作用。垂体切除后E作用的效力随着肝脏中ER含量的降低而平行下降。给垂体切除的雄性大鼠注射生长激素会导致ER水平升高，随后SEPB对E的阴性反应降低。得出的结论是，垂体因子可对性类固醇对SEPB水平的作用产生直接、致敏和允许作用。
